The effect of acute or chronic ether stress on plasma ACTH concentratiion in the rat

D. M. Cook, John Kendall, M. A. Greer, R. M. Kramer

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

This study was designed to measure changes in plasma ACTH (adrenocortical trophic hormone) concentration after ether exposure of 3 different durations or a 'psychological' stress. After 'psychological' stress (in a jar without ether for 30 sec) plasma ACTH concentration increased rapidly from a 9:00 AM 'basal' value of 23 138l7w2.w3=74.105.928 ± 4 (mean ± SE) to 71 ± 12 pg/ml at 2.5 min and returned to basal values within 20 min. After breathing an ether saturated atmosphere in a jar for 30 sec, plasma ACTH rose to 154 ± 30 pg/ml at 2.5 min but did not significantly decline by 40 min. With exposure to ether for 2.5 min, plasma ACTH rose to 384 ± 44 pg/ml at 2.5 min, fell significantly by 40 min and approached basal levels by 80 min after beginning ether. With continuous exposure to ether, plasma ACTH increased as in the 2.5 min ether experiment but the high values persisted for the entire 2 hr period of anesthesia. It is concluded that the magnitude and duration of the rise in plasma ACTH concentration are related to the duration and intensity of the ACTH releasing stimulus. There is no decrease in the ability to maintain elevated ACTH concentrations during 2 hr of ether anesthesia.

Original languageEnglish (US)
Pages (from-to)1019-1024
Number of pages6
JournalEndocrinology
Volume93
Issue number5
StatePublished - 1973

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Ether
Hormones
Psychological Stress
Anesthesia
Aptitude
Atmosphere
Respiration

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cook, D. M., Kendall, J., Greer, M. A., & Kramer, R. M. (1973). The effect of acute or chronic ether stress on plasma ACTH concentratiion in the rat. Endocrinology, 93(5), 1019-1024.

The effect of acute or chronic ether stress on plasma ACTH concentratiion in the rat. / Cook, D. M.; Kendall, John; Greer, M. A.; Kramer, R. M.

In: Endocrinology, Vol. 93, No. 5, 1973, p. 1019-1024.

Research output: Contribution to journalArticle

Cook, DM, Kendall, J, Greer, MA & Kramer, RM 1973, 'The effect of acute or chronic ether stress on plasma ACTH concentratiion in the rat', Endocrinology, vol. 93, no. 5, pp. 1019-1024.
Cook DM, Kendall J, Greer MA, Kramer RM. The effect of acute or chronic ether stress on plasma ACTH concentratiion in the rat. Endocrinology. 1973;93(5):1019-1024.
Cook, D. M. ; Kendall, John ; Greer, M. A. ; Kramer, R. M. / The effect of acute or chronic ether stress on plasma ACTH concentratiion in the rat. In: Endocrinology. 1973 ; Vol. 93, No. 5. pp. 1019-1024.
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