The effect of acute hypoxemia on coronary arterial dimensions in patients with coronary artery disease

Armin Arbab-Zadeh, Benjamin D. Levine, Jeffrey C. Trost, Richard A. Lange, Ellen C. Keeley, L. David Hillis, Joaquin Cigarroa

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Objectives: To assess the influence of acute hypoxemia on the dimensions of diseased and nondiseased coronary arterial segments in humans. Methods: In 18 subjects (age 53 ± 8 years) with known or suspected coronary artery disease, quantitative coronary angiography was performed before and after being randomly assigned to breathing (1) an inspired oxygen concentration (fraction of inspired oxygen, FIO2) of 21% (room air, RA) for 20 min (n = 4, controls) or (2) an FIO2 of 15 and 10% for 10 min each (corresponding to altitudes of 2,500 and 5,500 m, respectively; n = 14). Results: In the control subjects, no hemodynamic, oximetric or angiographic variable changed. In the 14 study subjects, the arterial partial pressure of oxygen averaged 85 ± 13 mm Hg on RA, 65 ± 15 mm Hg on 15% FIO2 and 44 ± 13 mm Hg on 10% FIO2. Average arterial segment diameter was 2.52 ± 0.63 mm on RA, 2.55 ± 0.62 mm on 15% FIO2 (not significant vs. RA) and 2.66 ± 0.66 mm on 10% FIO2 (p <0.001 vs. RA). The increase in coronary arterial diameter with 10% FIO 2 occurred only in normal segments (2.74 ± 0.64 vs. 2.97 ± 0.64 mm; p <0.001), but not in diseased segments (2.34 ± 0.57 vs. 2.38 ± 0.55 mm; not significant). Conclusions: In humans, severe hypoxemia induces vasodilation of angiographically normal coronary arterial segments, whereas it causes no change in diseased segments.

    Original languageEnglish (US)
    Pages (from-to)149-154
    Number of pages6
    JournalCardiology
    Volume113
    Issue number2
    DOIs
    StatePublished - Apr 2009

    Fingerprint

    Coronary Artery Disease
    Air
    Oxygen
    Partial Pressure
    Coronary Angiography
    Vasodilation
    Coronary Disease
    Arterial Pressure
    Respiration
    Hemodynamics
    Hypoxia

    Keywords

    • Atherosclerosis
    • Coronary heart disease
    • Hypoxia
    • Vasomotion

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Pharmacology (medical)

    Cite this

    Arbab-Zadeh, A., Levine, B. D., Trost, J. C., Lange, R. A., Keeley, E. C., Hillis, L. D., & Cigarroa, J. (2009). The effect of acute hypoxemia on coronary arterial dimensions in patients with coronary artery disease. Cardiology, 113(2), 149-154. https://doi.org/10.1159/000186695

    The effect of acute hypoxemia on coronary arterial dimensions in patients with coronary artery disease. / Arbab-Zadeh, Armin; Levine, Benjamin D.; Trost, Jeffrey C.; Lange, Richard A.; Keeley, Ellen C.; Hillis, L. David; Cigarroa, Joaquin.

    In: Cardiology, Vol. 113, No. 2, 04.2009, p. 149-154.

    Research output: Contribution to journalArticle

    Arbab-Zadeh, A, Levine, BD, Trost, JC, Lange, RA, Keeley, EC, Hillis, LD & Cigarroa, J 2009, 'The effect of acute hypoxemia on coronary arterial dimensions in patients with coronary artery disease', Cardiology, vol. 113, no. 2, pp. 149-154. https://doi.org/10.1159/000186695
    Arbab-Zadeh A, Levine BD, Trost JC, Lange RA, Keeley EC, Hillis LD et al. The effect of acute hypoxemia on coronary arterial dimensions in patients with coronary artery disease. Cardiology. 2009 Apr;113(2):149-154. https://doi.org/10.1159/000186695
    Arbab-Zadeh, Armin ; Levine, Benjamin D. ; Trost, Jeffrey C. ; Lange, Richard A. ; Keeley, Ellen C. ; Hillis, L. David ; Cigarroa, Joaquin. / The effect of acute hypoxemia on coronary arterial dimensions in patients with coronary artery disease. In: Cardiology. 2009 ; Vol. 113, No. 2. pp. 149-154.
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    abstract = "Objectives: To assess the influence of acute hypoxemia on the dimensions of diseased and nondiseased coronary arterial segments in humans. Methods: In 18 subjects (age 53 ± 8 years) with known or suspected coronary artery disease, quantitative coronary angiography was performed before and after being randomly assigned to breathing (1) an inspired oxygen concentration (fraction of inspired oxygen, FIO2) of 21{\%} (room air, RA) for 20 min (n = 4, controls) or (2) an FIO2 of 15 and 10{\%} for 10 min each (corresponding to altitudes of 2,500 and 5,500 m, respectively; n = 14). Results: In the control subjects, no hemodynamic, oximetric or angiographic variable changed. In the 14 study subjects, the arterial partial pressure of oxygen averaged 85 ± 13 mm Hg on RA, 65 ± 15 mm Hg on 15{\%} FIO2 and 44 ± 13 mm Hg on 10{\%} FIO2. Average arterial segment diameter was 2.52 ± 0.63 mm on RA, 2.55 ± 0.62 mm on 15{\%} FIO2 (not significant vs. RA) and 2.66 ± 0.66 mm on 10{\%} FIO2 (p <0.001 vs. RA). The increase in coronary arterial diameter with 10{\%} FIO 2 occurred only in normal segments (2.74 ± 0.64 vs. 2.97 ± 0.64 mm; p <0.001), but not in diseased segments (2.34 ± 0.57 vs. 2.38 ± 0.55 mm; not significant). Conclusions: In humans, severe hypoxemia induces vasodilation of angiographically normal coronary arterial segments, whereas it causes no change in diseased segments.",
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    AU - Levine, Benjamin D.

    AU - Trost, Jeffrey C.

    AU - Lange, Richard A.

    AU - Keeley, Ellen C.

    AU - Hillis, L. David

    AU - Cigarroa, Joaquin

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    N2 - Objectives: To assess the influence of acute hypoxemia on the dimensions of diseased and nondiseased coronary arterial segments in humans. Methods: In 18 subjects (age 53 ± 8 years) with known or suspected coronary artery disease, quantitative coronary angiography was performed before and after being randomly assigned to breathing (1) an inspired oxygen concentration (fraction of inspired oxygen, FIO2) of 21% (room air, RA) for 20 min (n = 4, controls) or (2) an FIO2 of 15 and 10% for 10 min each (corresponding to altitudes of 2,500 and 5,500 m, respectively; n = 14). Results: In the control subjects, no hemodynamic, oximetric or angiographic variable changed. In the 14 study subjects, the arterial partial pressure of oxygen averaged 85 ± 13 mm Hg on RA, 65 ± 15 mm Hg on 15% FIO2 and 44 ± 13 mm Hg on 10% FIO2. Average arterial segment diameter was 2.52 ± 0.63 mm on RA, 2.55 ± 0.62 mm on 15% FIO2 (not significant vs. RA) and 2.66 ± 0.66 mm on 10% FIO2 (p <0.001 vs. RA). The increase in coronary arterial diameter with 10% FIO 2 occurred only in normal segments (2.74 ± 0.64 vs. 2.97 ± 0.64 mm; p <0.001), but not in diseased segments (2.34 ± 0.57 vs. 2.38 ± 0.55 mm; not significant). Conclusions: In humans, severe hypoxemia induces vasodilation of angiographically normal coronary arterial segments, whereas it causes no change in diseased segments.

    AB - Objectives: To assess the influence of acute hypoxemia on the dimensions of diseased and nondiseased coronary arterial segments in humans. Methods: In 18 subjects (age 53 ± 8 years) with known or suspected coronary artery disease, quantitative coronary angiography was performed before and after being randomly assigned to breathing (1) an inspired oxygen concentration (fraction of inspired oxygen, FIO2) of 21% (room air, RA) for 20 min (n = 4, controls) or (2) an FIO2 of 15 and 10% for 10 min each (corresponding to altitudes of 2,500 and 5,500 m, respectively; n = 14). Results: In the control subjects, no hemodynamic, oximetric or angiographic variable changed. In the 14 study subjects, the arterial partial pressure of oxygen averaged 85 ± 13 mm Hg on RA, 65 ± 15 mm Hg on 15% FIO2 and 44 ± 13 mm Hg on 10% FIO2. Average arterial segment diameter was 2.52 ± 0.63 mm on RA, 2.55 ± 0.62 mm on 15% FIO2 (not significant vs. RA) and 2.66 ± 0.66 mm on 10% FIO2 (p <0.001 vs. RA). The increase in coronary arterial diameter with 10% FIO 2 occurred only in normal segments (2.74 ± 0.64 vs. 2.97 ± 0.64 mm; p <0.001), but not in diseased segments (2.34 ± 0.57 vs. 2.38 ± 0.55 mm; not significant). Conclusions: In humans, severe hypoxemia induces vasodilation of angiographically normal coronary arterial segments, whereas it causes no change in diseased segments.

    KW - Atherosclerosis

    KW - Coronary heart disease

    KW - Hypoxia

    KW - Vasomotion

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