The effect of acute hypoxaemia on ventricular function during beta-adrenergic and cholinergic blockade in the fetal sheep

Mark Reller, M. J. Morton, George Giraud, D. L. Reid, Kent Thornburg

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Abstract

The effect of acute hypoxaemia on right and left ventricular function was investigated in 8 fetal sheep (137-140 days gestation). Fetuses were instrumented with electromagnetic flow sensors on the ascending aorta and the main pulmonary artery. After 8 days recovery, hypoxaemia was achieved by reducing the maternal ewe's inspired O2 concentration to 13.1 ± 1.5%. Control and hypoxaemic arterial blood values were pH 7.37 ± 0.04 (SD) and 7.35 ± 0.06, PCO2 48.0 ± 2.8 and 47.6 ± 5.1 mmHg, PO2 19.9 ± 2.2 and 11.4 ± 1.5 mmHg, haematocrit 37.5 ± 1.2 and 39.5 ± 2.2%, respectively. Arterial pressure increased insignificantly with acute hypoxaemia (50.2 ± 3.9 to 53.6 ± 8.1 mmHg). Left and right ventricular performance was assessed by generating biventricular function curves relating stroke volume to mean atrial pressure. All function curves were composed of steep ascending and plateau limbs that intersected at a breakpoint. Comparing control and hypoxaemia function curves, the left ventricular stroke volume breakpoints were 0.79 ± 0.20 and 0.78 ± 0.21 ml/kg, respectively, while the right ventricular stroke volume breakpoints were 0.99 ± 0.11 and 0.88 ± 0.21 ml/kg (n.s.). In 4 fetuses, acute hypoxaemia was associated with significant increases in arterial blood pressure (P

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalJournal of Developmental Physiology
Volume11
Issue number4
StatePublished - 1989

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Ventricular Function
Adrenergic Agents
Cholinergic Agents
Sheep
Stroke Volume
Left Ventricular Function
Arterial Pressure
Fetus
Right Ventricular Function
Atrial Pressure
Electromagnetic Phenomena
Hematocrit
Pulmonary Artery
Aorta
Extremities
Mothers
Hypoxia
Pregnancy

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

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title = "The effect of acute hypoxaemia on ventricular function during beta-adrenergic and cholinergic blockade in the fetal sheep",
abstract = "The effect of acute hypoxaemia on right and left ventricular function was investigated in 8 fetal sheep (137-140 days gestation). Fetuses were instrumented with electromagnetic flow sensors on the ascending aorta and the main pulmonary artery. After 8 days recovery, hypoxaemia was achieved by reducing the maternal ewe's inspired O2 concentration to 13.1 ± 1.5{\%}. Control and hypoxaemic arterial blood values were pH 7.37 ± 0.04 (SD) and 7.35 ± 0.06, PCO2 48.0 ± 2.8 and 47.6 ± 5.1 mmHg, PO2 19.9 ± 2.2 and 11.4 ± 1.5 mmHg, haematocrit 37.5 ± 1.2 and 39.5 ± 2.2{\%}, respectively. Arterial pressure increased insignificantly with acute hypoxaemia (50.2 ± 3.9 to 53.6 ± 8.1 mmHg). Left and right ventricular performance was assessed by generating biventricular function curves relating stroke volume to mean atrial pressure. All function curves were composed of steep ascending and plateau limbs that intersected at a breakpoint. Comparing control and hypoxaemia function curves, the left ventricular stroke volume breakpoints were 0.79 ± 0.20 and 0.78 ± 0.21 ml/kg, respectively, while the right ventricular stroke volume breakpoints were 0.99 ± 0.11 and 0.88 ± 0.21 ml/kg (n.s.). In 4 fetuses, acute hypoxaemia was associated with significant increases in arterial blood pressure (P",
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T1 - The effect of acute hypoxaemia on ventricular function during beta-adrenergic and cholinergic blockade in the fetal sheep

AU - Reller, Mark

AU - Morton, M. J.

AU - Giraud, George

AU - Reid, D. L.

AU - Thornburg, Kent

PY - 1989

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N2 - The effect of acute hypoxaemia on right and left ventricular function was investigated in 8 fetal sheep (137-140 days gestation). Fetuses were instrumented with electromagnetic flow sensors on the ascending aorta and the main pulmonary artery. After 8 days recovery, hypoxaemia was achieved by reducing the maternal ewe's inspired O2 concentration to 13.1 ± 1.5%. Control and hypoxaemic arterial blood values were pH 7.37 ± 0.04 (SD) and 7.35 ± 0.06, PCO2 48.0 ± 2.8 and 47.6 ± 5.1 mmHg, PO2 19.9 ± 2.2 and 11.4 ± 1.5 mmHg, haematocrit 37.5 ± 1.2 and 39.5 ± 2.2%, respectively. Arterial pressure increased insignificantly with acute hypoxaemia (50.2 ± 3.9 to 53.6 ± 8.1 mmHg). Left and right ventricular performance was assessed by generating biventricular function curves relating stroke volume to mean atrial pressure. All function curves were composed of steep ascending and plateau limbs that intersected at a breakpoint. Comparing control and hypoxaemia function curves, the left ventricular stroke volume breakpoints were 0.79 ± 0.20 and 0.78 ± 0.21 ml/kg, respectively, while the right ventricular stroke volume breakpoints were 0.99 ± 0.11 and 0.88 ± 0.21 ml/kg (n.s.). In 4 fetuses, acute hypoxaemia was associated with significant increases in arterial blood pressure (P

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