The effect of acute hyperglycemia on meal stimulated gastric, biliary, and pancreatic secretion, and serum gastrin

I. L. MacGregor, Clifford Deveney, L. W. Way, J. H. Meyer

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The effects of hyperglycemia on pancreatic, biliary and gastric secretory responses to meals have not been hitherto quantified in man. In the present study seven normal volunteers were fed on two occasions a 500 ml liquid test meal containing fat and protein. During one of the meals the subjects were made acutely hyperglycemic with intravenous glucose, whereas in control experiments, each subject received intravenous saline in place of glucose. A jejunal perfusion method was used to measure pancreatic output of trypsin and biliary outputs of bile salts for 150 min after the meal; the same method was used to quantify indirectly the amount of acid secreted by the stomach in the 150 min period. Serum gastrins were also measured basally and at intervals after the meal. Hyperglycemia suppressed serum gastrin, gastric acid production, trypsin secretion, and bile salt output in response to the test meal.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalGastroenterology
Volume70
Issue number2
StatePublished - 1976
Externally publishedYes

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Gastrins
Hyperglycemia
Meals
Stomach
Serum
Bile Acids and Salts
Trypsin
Glucose
Gastric Acid
Healthy Volunteers
Perfusion
Fats
Acids
Proteins

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The effect of acute hyperglycemia on meal stimulated gastric, biliary, and pancreatic secretion, and serum gastrin. / MacGregor, I. L.; Deveney, Clifford; Way, L. W.; Meyer, J. H.

In: Gastroenterology, Vol. 70, No. 2, 1976, p. 197-202.

Research output: Contribution to journalArticle

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