The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory

R. H. Goodman; J. B. Flexner; L. B. Flexner

doi:10.1073/pnas.72.2.479

The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory

R. H. Goodman, J. B. Flexner, L. B. Flexner

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Abstract

The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severely decreased for a period of 12 hr after injection. Total catecholamine levels were increased from 1 to 4 hr, then decreased 17 hr following injection. These results are discussed in terms of previous behavioral observations. It is pointed out that they weaken the assumption that acetoxycycloheximide's amnestic effects are solely due to inhibition of protein synthesis.

Original language	English (US)
Pages (from-to)	479-482
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	72
Issue number	2
DOIs	https://doi.org/10.1073/pnas.72.2.479
State	Published - 1975
Externally published	Yes

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The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory. / Goodman, R. H.; Flexner, J. B.; Flexner, L. B.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 72, No. 2, 1975, p. 479-482.

Research output: Contribution to journal › Article › peer-review

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The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory

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