The effect of 3',5' adenosine monophosphate on granulocyte adhesion

R. E. Bryant, M. C. Sutcliffe

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5' adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10-3 to 10-4 M dibutyryl cAMP. 10-4 to 10-6 M prostaglandin E1 (PGE1), 10-4 to 10-6 M histamine, or 10-3 M theophylline. Adhesion was not suppressed by 10-4 M theophylline unless it was combined with PGE1 or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in the regulation of adhesiveness of human basophils, eosinophils, and neutrophils.

Original languageEnglish (US)
Pages (from-to)1241-1244
Number of pages4
JournalJournal of Clinical Investigation
Issue number5
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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