The effect of 3',5' adenosine monophosphate on granulocyte adhesion

R. E. Bryant; M. C. Sutcliffe

doi:10.1172/JCI107868

The effect of 3',5' adenosine monophosphate on granulocyte adhesion

R. E. Bryant, M. C. Sutcliffe

Research output: Contribution to journal › Article › peer-review

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Abstract

Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5' adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10^-3 to 10^-4 M dibutyryl cAMP. 10^-4 to 10^-6 M prostaglandin E1 (PGE1), 10^-4 to 10^-6 M histamine, or 10^-3 M theophylline. Adhesion was not suppressed by 10^-4 M theophylline unless it was combined with PGE1 or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in the regulation of adhesiveness of human basophils, eosinophils, and neutrophils.

Original language	English (US)
Pages (from-to)	1241-1244
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	54
Issue number	5
DOIs	https://doi.org/10.1172/JCI107868
State	Published - 1974
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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abstract = "Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5' adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10-3 to 10-4 M dibutyryl cAMP. 10-4 to 10-6 M prostaglandin E1 (PGE1), 10-4 to 10-6 M histamine, or 10-3 M theophylline. Adhesion was not suppressed by 10-4 M theophylline unless it was combined with PGE1 or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in the regulation of adhesiveness of human basophils, eosinophils, and neutrophils.",

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AB - Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5' adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10-3 to 10-4 M dibutyryl cAMP. 10-4 to 10-6 M prostaglandin E1 (PGE1), 10-4 to 10-6 M histamine, or 10-3 M theophylline. Adhesion was not suppressed by 10-4 M theophylline unless it was combined with PGE1 or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in the regulation of adhesiveness of human basophils, eosinophils, and neutrophils.

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The effect of 3',5' adenosine monophosphate on granulocyte adhesion

Abstract

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