Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5' adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10-3 to 10-4 M dibutyryl cAMP. 10-4 to 10-6 M prostaglandin E1 (PGE1), 10-4 to 10-6 M histamine, or 10-3 M theophylline. Adhesion was not suppressed by 10-4 M theophylline unless it was combined with PGE1 or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in the regulation of adhesiveness of human basophils, eosinophils, and neutrophils.
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