The economics of neurite outgrowth - The addition of new membrane to growing axons

Anthony H. Futerman, Gary Banker

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Recent studies have shown that axonal growth is disrupted by treatments that block the synthesis of membrane components or their delivery by microtubule-based transport. This implies that a continuous supply of newly synthesized membrane components is necessary to sustain growth. In contrast, no clear consensus has yet been achieved about the site of insertion of new membrane components in the membrane of the growing axon, despite the application of new and refined biophysical and molecular techniques to the study of this issue. Until the site of insertion of new membrane components is resolved, little progress can be made in defining the feedback mechanisms by which the supply of new membrane components is co-ordinated with the demands of growth, particularly in cases where the dynamics of neurite growth change from minute to minute.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalTrends in Neurosciences
Volume19
Issue number4
DOIs
StatePublished - Apr 1996
Externally publishedYes

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Axons
Economics
Membranes
Growth
Neurites
Microtubules
Neuronal Outgrowth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The economics of neurite outgrowth - The addition of new membrane to growing axons. / Futerman, Anthony H.; Banker, Gary.

In: Trends in Neurosciences, Vol. 19, No. 4, 04.1996, p. 144-149.

Research output: Contribution to journalArticle

Futerman, Anthony H. ; Banker, Gary. / The economics of neurite outgrowth - The addition of new membrane to growing axons. In: Trends in Neurosciences. 1996 ; Vol. 19, No. 4. pp. 144-149.
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