Abstract
Objective: To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age. Methods: Infants with bilateral high-risk prethreshold ROP had one eye randomly assigned to treatment with peripheral retinal ablation. The fellow eye was managed conventionally, and either treated at threshold ROP or observed if threshold was never reached. In patients with asymmetrical disease, the high-risk, prethreshold eye was randomised to earlier treatment or to conventional management. At 2 years of age, children were examined comprehensively by certified ophthalmologists to determine structural outcomes for their eyes. For the purposes of this study, an unfavourable structural outcome was defined as (1) a posterior retinal fold involving the macula, (2) a retinal detachment involving the macula or (3) retrolental tissue or "mass" obscuring the view of the posterior pole. Results of the 2-year examination were compared with those from the 9 months examination. Results: Data were available on 339 of 374 (90.6%) surviving children. Unfavourable structural outcomes were reduced from 15.4% in conventionally managed eyes to 9.1% in earlier-treated eyes (p = 0.002) at 2 years of age. Ophthalmic side effects (excluding retinal structure) from the ROP or its treatment were similar in the earlier-treated eyes and the conventionally managed eyes. Conclusion: The benefit of earlier treatment of high-risk prethreshold ROP on retinal structure endures to 2 years of age, and is not counterbalanced by any known side effect caused by earlier intervention. Earlier treatment improves the chance for long-term favourable retinal structural outcome in eyes with high-risk prethreshold ROP. Long-term follow-up is planned to determine structural and functional outcomes at 6 years of age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1378-1382 |
| Number of pages | 5 |
| Journal | British Journal of Ophthalmology |
| Volume | 90 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2006 |
| Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
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The early treatment for retinopathy of prematurity study : Structural findings at age 2 years. / Good, William V.; Hardy, Robert J.; Dobson, Velma; Palmer, Earl A.; Phelps, Dale L.; Quintos, Michelle; Tung, Betty; Madan, Ashima; Ball, M. Bethany; Hartsell, Patricia N.; Inguillo, Dottie; Gaynon, Michael; Alcorn, Deborah; Ornitz, Donna; Gancasz, Judith; Durand, David; Slagle, Terri; Smith, Gordon; Shapiro, Michael; Garcia, Yesenia; Genio, Maria; Bloom, Jeffrey N.; Kaufman, Lawrence; Lai, Wico Waikwan; Miller, Marilyn; Neely, Daniel; Hynes, Elizabeth A.; Lemons, James; Plager, David; Sondhi, Naval; Sprunger, Derek; Rychwalski, Paul J.; Whittington, Greg K.; Fishman, Peggy H.; Gordon, Robert A.; Neff, Deborah S.; Babel, Douglas B.; Diamond, James G.; Gill, William L.; Steidl, Scott M.; Hutcheson, Kelly A.; Powdrill, Kevin; Jones, Eric; Preslan, Mark W.; Repka, Michael X.; Shepard, Jennifer A.; Donahue, Pamela; Aucott, Susan W.; Collins, Mary Louise Z.; Gilmore, Maureen M.; Handa, James T.; Cole, Cynthia H.; VanderVeen, Deborah; Mansfield, Terri; MacKinnon, Brenda; Fraioli, Anthony; McCabe, O'ine; Peterson, Robert; Hunter, David; MacKinnon, Sarah; Johnson, Rhiannon; Tyedmers, Mariette; Baker, John; Cumming, Krist; Manatrey, Pat; Capone, Antonio; O'Malley, Edward; Rao, Rajesh; Roarty, John; Trese, Michael; Williams, George; Christiansen, Stephen P.; Cook, Sally; Holleschau, Ann; Summers, C. Gail; Davitt, Bradley V.; Breuer, Linda; Cruz, Oscar; Keenan, William; Mantych, Greg; Lueder, Gregg; Freedman, Sharon; Wallace, David; Parkman, Lori Hutchins; Jones, Sarah; Enyedi, Laura; Reynolds, James D.; Ziemann, Kristine; Albert, George P.; Awner, Steven; Ryan, Rita; Weber, Pamela Ann; Horowitz, Marc; Behrendt, Cherylene; Dweck, Natalie; Koty, Richard; LaGamma, Edmund; Flynn, John; Lee, Thomas C.; Coki, Osode; Chiang, Michael; Kane, Steven; Polin, Richard; Horihan, Cassandra; Phillips, Jane; Markowitz, Gary; Merriam, Walter; Noel, Leon Paul; Tingley, Donald; Gearinger, Matthew; Rogers, Gary L.; Bremer, Don; Fellows, Rae; Klamfoth, Sharon; Arthur, Brian; Cassady, Cybil Bean; Cordero, Leandro; Golden, Richard; Hertle, Richard; McClead, Richard; McGregor, Mary Lou; Siatkowski, R. Michael; Ogilbee, Lisa; Harris, Cheryl; Bradford, Reagan H.; Leonard, Robert E.; McCaffree, Mary Anne; Wheeler, David T.; Dolphin, Nancy; Stout, Ann; Nichols, Brian; Epley, David; Quinn, Graham E.; Koh, Jamie G.; Abbasi, Soraya; Edmond, Jane C.; Forbes, Brian J.; Maguire, Albert M.; Mills, Monte D.; Young, Terri L.; Davidson, Stephanie; Cheng, Kenneth; Jones, Judith; Bergren, Robert; Brozanski, Beverly; Doft, Bernard; Lobes, Louis; Olsen, Karl; Saunders, Richard A.; Stevens, Linda; Peterseim, M. Millicent; Wilson, Edward; Purohit, Dilip; Coats, David K.; Parker, Michele L.; Castanes, Maria; Paysee, Evelyn A.; Yen, Kimberly G.; Garcia-Prats, Joseph; Van Heuven, W. A.J.; Trigo, Yolanda; MacDonald, James C.; Hoffman, Robert; Bracken, Susan; Bernstein, Paul; King, Jerald; Teske, Michael; Redford, Maryann; Mowery, Richard L.; Everett, Donald F.; Pedroza, Claudia; Tsai, Gordon; Connett, John; Donovan, Edward F.; Hillis, Argye; Holmes, Jonathan M.; Miller, Joseph M.; Taylor, Carol R.; Barr, Charles.
In: British Journal of Ophthalmology, Vol. 90, No. 11, 11.2006, p. 1378-1382.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The early treatment for retinopathy of prematurity study
T2 - Structural findings at age 2 years
AU - Good, William V.
AU - Hardy, Robert J.
AU - Dobson, Velma
AU - Palmer, Earl A.
AU - Phelps, Dale L.
AU - Quintos, Michelle
AU - Tung, Betty
AU - Madan, Ashima
AU - Ball, M. Bethany
AU - Hartsell, Patricia N.
AU - Inguillo, Dottie
AU - Gaynon, Michael
AU - Alcorn, Deborah
AU - Ornitz, Donna
AU - Gancasz, Judith
AU - Durand, David
AU - Slagle, Terri
AU - Smith, Gordon
AU - Shapiro, Michael
AU - Garcia, Yesenia
AU - Genio, Maria
AU - Bloom, Jeffrey N.
AU - Kaufman, Lawrence
AU - Lai, Wico Waikwan
AU - Miller, Marilyn
AU - Neely, Daniel
AU - Hynes, Elizabeth A.
AU - Lemons, James
AU - Plager, David
AU - Sondhi, Naval
AU - Sprunger, Derek
AU - Rychwalski, Paul J.
AU - Whittington, Greg K.
AU - Fishman, Peggy H.
AU - Gordon, Robert A.
AU - Neff, Deborah S.
AU - Babel, Douglas B.
AU - Diamond, James G.
AU - Gill, William L.
AU - Steidl, Scott M.
AU - Hutcheson, Kelly A.
AU - Powdrill, Kevin
AU - Jones, Eric
AU - Preslan, Mark W.
AU - Repka, Michael X.
AU - Shepard, Jennifer A.
AU - Donahue, Pamela
AU - Aucott, Susan W.
AU - Collins, Mary Louise Z.
AU - Gilmore, Maureen M.
AU - Handa, James T.
AU - Cole, Cynthia H.
AU - VanderVeen, Deborah
AU - Mansfield, Terri
AU - MacKinnon, Brenda
AU - Fraioli, Anthony
AU - McCabe, O'ine
AU - Peterson, Robert
AU - Hunter, David
AU - MacKinnon, Sarah
AU - Johnson, Rhiannon
AU - Tyedmers, Mariette
AU - Baker, John
AU - Cumming, Krist
AU - Manatrey, Pat
AU - Capone, Antonio
AU - O'Malley, Edward
AU - Rao, Rajesh
AU - Roarty, John
AU - Trese, Michael
AU - Williams, George
AU - Christiansen, Stephen P.
AU - Cook, Sally
AU - Holleschau, Ann
AU - Summers, C. Gail
AU - Davitt, Bradley V.
AU - Breuer, Linda
AU - Cruz, Oscar
AU - Keenan, William
AU - Mantych, Greg
AU - Lueder, Gregg
AU - Freedman, Sharon
AU - Wallace, David
AU - Parkman, Lori Hutchins
AU - Jones, Sarah
AU - Enyedi, Laura
AU - Reynolds, James D.
AU - Ziemann, Kristine
AU - Albert, George P.
AU - Awner, Steven
AU - Ryan, Rita
AU - Weber, Pamela Ann
AU - Horowitz, Marc
AU - Behrendt, Cherylene
AU - Dweck, Natalie
AU - Koty, Richard
AU - LaGamma, Edmund
AU - Flynn, John
AU - Lee, Thomas C.
AU - Coki, Osode
AU - Chiang, Michael
AU - Kane, Steven
AU - Polin, Richard
AU - Horihan, Cassandra
AU - Phillips, Jane
AU - Markowitz, Gary
AU - Merriam, Walter
AU - Noel, Leon Paul
AU - Tingley, Donald
AU - Gearinger, Matthew
AU - Rogers, Gary L.
AU - Bremer, Don
AU - Fellows, Rae
AU - Klamfoth, Sharon
AU - Arthur, Brian
AU - Cassady, Cybil Bean
AU - Cordero, Leandro
AU - Golden, Richard
AU - Hertle, Richard
AU - McClead, Richard
AU - McGregor, Mary Lou
AU - Siatkowski, R. Michael
AU - Ogilbee, Lisa
AU - Harris, Cheryl
AU - Bradford, Reagan H.
AU - Leonard, Robert E.
AU - McCaffree, Mary Anne
AU - Wheeler, David T.
AU - Dolphin, Nancy
AU - Stout, Ann
AU - Nichols, Brian
AU - Epley, David
AU - Quinn, Graham E.
AU - Koh, Jamie G.
AU - Abbasi, Soraya
AU - Edmond, Jane C.
AU - Forbes, Brian J.
AU - Maguire, Albert M.
AU - Mills, Monte D.
AU - Young, Terri L.
AU - Davidson, Stephanie
AU - Cheng, Kenneth
AU - Jones, Judith
AU - Bergren, Robert
AU - Brozanski, Beverly
AU - Doft, Bernard
AU - Lobes, Louis
AU - Olsen, Karl
AU - Saunders, Richard A.
AU - Stevens, Linda
AU - Peterseim, M. Millicent
AU - Wilson, Edward
AU - Purohit, Dilip
AU - Coats, David K.
AU - Parker, Michele L.
AU - Castanes, Maria
AU - Paysee, Evelyn A.
AU - Yen, Kimberly G.
AU - Garcia-Prats, Joseph
AU - Van Heuven, W. A.J.
AU - Trigo, Yolanda
AU - MacDonald, James C.
AU - Hoffman, Robert
AU - Bracken, Susan
AU - Bernstein, Paul
AU - King, Jerald
AU - Teske, Michael
AU - Redford, Maryann
AU - Mowery, Richard L.
AU - Everett, Donald F.
AU - Pedroza, Claudia
AU - Tsai, Gordon
AU - Connett, John
AU - Donovan, Edward F.
AU - Hillis, Argye
AU - Holmes, Jonathan M.
AU - Miller, Joseph M.
AU - Taylor, Carol R.
AU - Barr, Charles
PY - 2006/11
Y1 - 2006/11
N2 - Objective: To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age. Methods: Infants with bilateral high-risk prethreshold ROP had one eye randomly assigned to treatment with peripheral retinal ablation. The fellow eye was managed conventionally, and either treated at threshold ROP or observed if threshold was never reached. In patients with asymmetrical disease, the high-risk, prethreshold eye was randomised to earlier treatment or to conventional management. At 2 years of age, children were examined comprehensively by certified ophthalmologists to determine structural outcomes for their eyes. For the purposes of this study, an unfavourable structural outcome was defined as (1) a posterior retinal fold involving the macula, (2) a retinal detachment involving the macula or (3) retrolental tissue or "mass" obscuring the view of the posterior pole. Results of the 2-year examination were compared with those from the 9 months examination. Results: Data were available on 339 of 374 (90.6%) surviving children. Unfavourable structural outcomes were reduced from 15.4% in conventionally managed eyes to 9.1% in earlier-treated eyes (p = 0.002) at 2 years of age. Ophthalmic side effects (excluding retinal structure) from the ROP or its treatment were similar in the earlier-treated eyes and the conventionally managed eyes. Conclusion: The benefit of earlier treatment of high-risk prethreshold ROP on retinal structure endures to 2 years of age, and is not counterbalanced by any known side effect caused by earlier intervention. Earlier treatment improves the chance for long-term favourable retinal structural outcome in eyes with high-risk prethreshold ROP. Long-term follow-up is planned to determine structural and functional outcomes at 6 years of age.
AB - Objective: To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age. Methods: Infants with bilateral high-risk prethreshold ROP had one eye randomly assigned to treatment with peripheral retinal ablation. The fellow eye was managed conventionally, and either treated at threshold ROP or observed if threshold was never reached. In patients with asymmetrical disease, the high-risk, prethreshold eye was randomised to earlier treatment or to conventional management. At 2 years of age, children were examined comprehensively by certified ophthalmologists to determine structural outcomes for their eyes. For the purposes of this study, an unfavourable structural outcome was defined as (1) a posterior retinal fold involving the macula, (2) a retinal detachment involving the macula or (3) retrolental tissue or "mass" obscuring the view of the posterior pole. Results of the 2-year examination were compared with those from the 9 months examination. Results: Data were available on 339 of 374 (90.6%) surviving children. Unfavourable structural outcomes were reduced from 15.4% in conventionally managed eyes to 9.1% in earlier-treated eyes (p = 0.002) at 2 years of age. Ophthalmic side effects (excluding retinal structure) from the ROP or its treatment were similar in the earlier-treated eyes and the conventionally managed eyes. Conclusion: The benefit of earlier treatment of high-risk prethreshold ROP on retinal structure endures to 2 years of age, and is not counterbalanced by any known side effect caused by earlier intervention. Earlier treatment improves the chance for long-term favourable retinal structural outcome in eyes with high-risk prethreshold ROP. Long-term follow-up is planned to determine structural and functional outcomes at 6 years of age.
UR - http://www.scopus.com/inward/record.url?scp=33750706543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750706543&partnerID=8YFLogxK
U2 - 10.1136/bjo.2006.098582
DO - 10.1136/bjo.2006.098582
M3 - Article
C2 - 16914473
AN - SCOPUS:33750706543
VL - 90
SP - 1378
EP - 1382
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 11
ER -