TY - JOUR
T1 - The EADC-ADNI harmonized protocol for manual hippocampal segmentation on magnetic resonance
T2 - Evidence of validity
AU - Frisoni, Giovanni B.
AU - Jack, Clifford R.
AU - Bocchetta, Martina
AU - Bauer, Corinna
AU - Frederiksen, Kristian S.
AU - Liu, Yawu
AU - Preboske, Gregory
AU - Swihart, Tim
AU - Blair, Melanie
AU - Cavedo, Enrica
AU - Grothe, Michel J.
AU - Lanfredi, Mariangela
AU - Martinez, Oliver
AU - Nishikawa, Masami
AU - Portegies, Marileen
AU - Stoub, Travis
AU - Ward, Chadwich
AU - Apostolova, Liana G.
AU - Ganzola, Rossana
AU - Wolf, Dominik
AU - Barkhof, Frederik
AU - Bartzokis, George
AU - DeCarli, Charles
AU - Csernansky, John G.
AU - Detoledo-Morrell, Leyla
AU - Geerlings, Mirjam I.
AU - Kaye, Jeffrey
AU - Killiany, Ronald J.
AU - Lehericy, Stephane
AU - Matsuda, Hiroshi
AU - O'Brien, John
AU - Silbert, Lisa C.
AU - Scheltens, Philip
AU - Soininen, Hilkka
AU - Teipel, Stefan
AU - Waldemar, Gunhild
AU - Fellgiebel, Andreas
AU - Barnes, Josephine
AU - Firbank, Michael
AU - Gerritsen, Lotte
AU - Henneman, Wouter
AU - Malykhin, Nikolai
AU - Pruessner, Jens C.
AU - Wang, Lei
AU - Watsonl, Craig
AU - Wolf, Henrike
AU - Deleon, Mony
AU - Pantel, Johannes
AU - Ferrari, Clarissa
AU - Bosco, Paolo
AU - Pasqualetti, Patrizio
AU - Duchesne, Simon
AU - Duvernoy, Henri
AU - Boccardi, Marina
AU - Albert, Marilyn S.
AU - Bennet, David
AU - Camicioli, Richard
AU - Collins, D. Louis
AU - Dubois, Bruno
AU - Hampel, Harald
AU - Denheijer, Tom
AU - Hock, Christofer
AU - Jagust, William
AU - Launer, Leonore
AU - Maller, Jerome J.
AU - Mueller, Susan
AU - Sachdev, Perminder
AU - Simmons, Andy
AU - Thompson, Paul M.
AU - Visser, Peter Jelle
AU - Wahlund, Lars Olof
AU - Weiner, Michael W.
AU - Winblad, Bengt
N1 - Funding Information:
Josephine Barnes is an Alzheimer's Research UK senior research fellow based at the Dementia Research Centre, Department of Neurodegenerative Disease, UCL, Institute of Neurology. The Dementia Research Centre is an Alzheimer's Research UK Coordinating Centre and has also received equipment funded by Alzheimer's Research UK and Brain Research Trust . Part of this work was supported by the NIHR Queen Square Dementia BRU .
Funding Information:
Preparatory work (reported in Boccardi et al., J Alzheimers Dis, 2011; 26:61-75 and in Boccardi et al, Alzheimer's and Dementia 2013, doi:pii: S1552-5260(13)00078-2) was funded by unrestricted grants from Lilly International and Wyeth International (a part of the Pfizer group).
Funding Information:
The “Harmonized Protocol For Manual Hippocampal Segmentation: An EADC-ADNI Effort” has been funded thanks to an unrestricted grant from the Alzheimer's Association (grant number IIRG-10-174022 ). The project PI is Giovanni B Frisoni, IRCCS Fatebenefratelli, Brescia, Italy; the co-PI is Clifford R. Jack, Mayo Clinic, Rochester, MN; the Statistical Working Group is led by Simon Duchesne, Laval University, Quebec City, Canada; project Coordinator is Marina Boccardi, IRCCS Fatebenefratelli, Brescia, Italy. EADC Centres (local P.I.) are: IRCCS Fatebenefratelli, Brescia, Italy (GB Frisoni); University of Kuopio and Kuopio University Hospital, Kuopio, Finland (H Soininen); Höpital Salpètriere, Paris, France (B Dubois and S Lehericy); University of Frankfurt, Frankfurt, Germany (H Hampel); University Rostock and DZNE, Rostock, Germany (S Teipel); Karolinska institutet, Stockholm, Sweden (L-O Wahlund); Department of Psychiatry Research, Zurich, Switzerland (C Hock); Alzheimer Centre, Vrije Univ Medical Centre, Amsterdam, The Netherlands (F Barkhof and P Scheltens); Dementia Research Group Institute of Neurology, London, United Kingdom (N Fox); Dep. of Psychiatry and Psychotherapy, University Medical Center, Mainz (A. Fellgiebel); NEUROMED, Department of Neuroimaging, King's College London, London, United Kingdom (A Simmons). ADNI Centres are: Mayo Clinic, Rochester, MN (CR Jack); University of California Davis, CA (C DeCarli and C Watson); University of California, Los Angeles (UCLA), CA (G Bartzokis); University of California San Francisco (UCSF), CA (M Weiner and S Mueller); University of California, Los Angeles (UCLA), CA (LG Apostolova); Laboratory of NeuroImaging (LoNI), University of Southern California, Los Angeles, CA (PM Thompson); Rush University Medical Center, Chicago, IL (L deToledo-Morrell); Rush Alzheimer's Disease Center, Chicago, IL (D Bennet); Northwestern University, IL (JG Csernansky); Boston University School of Medicine, MA (R Killiany); John Hopkins University, Baltimore, MD (M Albert); Center for Brain Health, New York, NY (M De Leon); Oregon Health & Science University, Portland, OR (J Kaye). Other Centres are: McGill University, Montreal, Quebec, Canada (J Pruessner); University of Alberta, Edmonton, AB, Canada (R Camicioli and N Malykhin); Department of Psychiatry, Psychosomatic, Medicine & Psychotherapy, Johann, Wolfgang Goethe-University, Frankfurt, Germany (J Pantel); Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, United Kingdom (J O'Brien). Population based Studies: PATH through life, Australia (P Sachdev and JJ Maller); SMART-Medea Study, University Medical Center Utrecht, The Netherlands (MI Geerlings); Rotterdam Scan Study, The Netherlands (T denHeijer). Statistical Working Group: AFAR (Fatebenefratelli Association for Biomedical Research) San Giovanni Calibita - Fatebenefratelli Hospital - Rome, Italy (P Pasqualetti); Laval University, Quebec City, Canada (S Duchesne); MNI, McGill University, Montreal, Canada (L Collins). Advisors: Clinical issues: PJ Visser, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands; EADC PIs: B Winbald, Karolinska Institute, Sweden and L Froelich, Central Institute of Mental Health, Mannheim, Germany; Dissemination & Education: G Waldemar, Copenhagen University Hospital, Copenhagen, Denmark; ADNI PI: M Weiner, University of California San Francisco (UCSF), CA; Population Studies: L Launer, National Institute on Aging (NIA), Bethesda and W Jagust, University of California, Berkeley, CA.
Funding Information:
Contribution by Tim Swihart, Lisa C Silbert and Jeffrey Kaye was supported by NIH / NIA ADC P30 grant ( P30 AG008017 ). Contribution by Stephane Lehéricy was supported by the grant: “ Investissements d'avenir ” (grant number ANR-10-IAIHU-06 ).
Funding Information:
The Statistical Working Group is co-funded through an international collaborative grant from the Ministère du Développement Économique, de l'Innovation et de l'Exportation of Quebec.
Publisher Copyright:
© 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Background: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P <.001), and physiological variability (49.2%, P <.001). Conclusions: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.
AB - Background: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P <.001), and physiological variability (49.2%, P <.001). Conclusions: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.
KW - Alzheimer's disease
KW - Biomarkers
KW - Clinical trials
KW - Diagnostic criteria
KW - Enrichment
KW - Harmonized protocol
KW - Hippocampal volumetry
KW - Magnetic resonance
KW - Manual segmentation
KW - Standard operating procedures
KW - Validation
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U2 - 10.1016/j.jalz.2014.05.1756
DO - 10.1016/j.jalz.2014.05.1756
M3 - Article
C2 - 25267715
AN - SCOPUS:84929158989
VL - 11
SP - 111
EP - 125
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
IS - 2
ER -