The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4

Jennifer Egan, Kirk Lalwani, Catherine Marcucci

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a pharmacokinetic interaction between carbamazepine and alprazolam leading to sedation. Alprazolam is a cytochrome P450 3A4 substrate. Carbamazapine is a 3A4 inducer. Discontinuation of carbamazepine leads to less metabolism of alprazolam and greater sedation.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages385-387
Number of pages3
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

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Alprazolam
Cytochrome P-450 CYP3A
Carbamazepine
Pharmacokinetics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Egan, J., Lalwani, K., & Marcucci, C. (2015). The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 385-387). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_82

The distressed daughter : Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4. / Egan, Jennifer; Lalwani, Kirk; Marcucci, Catherine.

A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 385-387.

Research output: Chapter in Book/Report/Conference proceedingChapter

Egan, J, Lalwani, K & Marcucci, C 2015, The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4. in A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, pp. 385-387. https://doi.org/10.1007/978-1-4614-7495-1_82
Egan J, Lalwani K, Marcucci C. The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4. In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York. 2015. p. 385-387 https://doi.org/10.1007/978-1-4614-7495-1_82
Egan, Jennifer ; Lalwani, Kirk ; Marcucci, Catherine. / The distressed daughter : Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4. A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. pp. 385-387
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