The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4

Jennifer Egan, Kirk Lalwani, Catherine Marcucci

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a pharmacokinetic interaction between carbamazepine and alprazolam leading to sedation. Alprazolam is a cytochrome P450 3A4 substrate. Carbamazapine is a 3A4 inducer. Discontinuation of carbamazepine leads to less metabolism of alprazolam and greater sedation.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages385-387
Number of pages3
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • Medicine(all)

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