The development of Pneumocystis carinii pneumonia in germ-free rats requires immunosuppression and exposure to the Pneumocystis carinii organism

L. Wolff, S. Horch, D. Gemsa

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Adult germ-free rats treated with dexamethasone and exposed to a non-sterile environment did not harbor or develop Pneumocystis carinii cysts or trophozoites after 10 weeks of immunosuppression. Only when they were exposed to infected, conventional rats and treated with dexamethasone for 8 weeks or longer, did adult germ-free rats develop P. carinii infection.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume16
Issue number1
DOIs
StatePublished - Jan 1993

Keywords

  • Pneumocystis carinii
  • immunosuppression
  • rats

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Immunology
  • veterinary(all)
  • Infectious Diseases

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