The development of Pneumocystis carinii pneumonia in germ-free rats requires immunosuppression and exposure to the Pneumocystis carinii organism

Lawrence Wolff, S. Horch, D. Gemsa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Adult germ-free rats treated with dexamethasone and exposed to a non-sterile environment did not harbor or develop Pneumocystis carinii cysts or trophozoites after 10 weeks of immunosuppression. Only when they were exposed to infected, conventional rats and treated with dexamethasone for 8 weeks or longer, did adult germ-free rats develop P. carinii infection.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume16
Issue number1
DOIs
StatePublished - 1993

Fingerprint

Pneumocystis carinii
Pneumocystis Pneumonia
immunosuppression
Immunosuppression
pneumonia
dexamethasone
Dexamethasone
rats
organisms
Pneumocystis Infections
Trophozoites
trophozoites
Cysts
infection

Keywords

  • immunosuppression
  • Pneumocystis carinii
  • rats

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • Microbiology
  • veterinary(all)

Cite this

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