The determinants of bone mineral density in Chinese men - Results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men

E. M.C. Lau, P. C. Leung, T. Kwok, J. Woo, H. Lynn, E. Orwoll, S. Cummings, J. Cauley

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Mr. Os (Hong Kong) is the first study to address the risk factors for osteoporosis in Asian men. A standardized, structured interview and dual X-ray densitometry (DEXA) were performed on 2,000 Chinese men aged 65-92. By multiple regression, the following factors were found to be positively associated with BMD at both the total hip and the spine: body weight, grip strength and a history of diabetes mellitus. The following factors were found to be negatively associated with BMD at both the total hip and spine: cigarette smoking, a history of gastrectomy or bowel resection, current use of inhaled steroid and a history of fracture after 50 years. Moreover, a history of chronic obstructive pulmonary disease (COPD) was negatively associated with BMD at the total hip, and age, the use of an alpha-blocker, thiazide diuretic and nitrate were associated with a higher BMD at the spine. A total of 21.8% of the variance in total hip and 31.5% of the variance in total spine BMD was accounted for in the multivariate analysis.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalOsteoporosis International
Volume17
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Asian men
  • Cigarette smoking
  • Corticosteroid
  • Medical factors
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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