The dentin organic matrix - Limitations of restorative dentistry hidden on the nanometer scale

Luiz Bertassoni, Joseph P R Orgel, Olga Antipova, Michael V. Swain

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The prevention and treatment of dental caries are major challenges occurring in dentistry. The foundations for modern management of this dental disease, estimated to affect 90% of adults in Western countries, rest upon the dependence of ultrafine interactions between synthetic polymeric biomaterials and nanostructured supramolecular assemblies that compose the tooth organic substrate. Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations. Here we review progress in the identification of the nanostructural organization of the organic matrix of dentin, the largest component of the tooth structure, and highlight aspects relevant to understating the interaction of restorative biomaterials with the dentin substrate. We offer novel insights into the influence of the hierarchically assembled supramolecular structure of dentin collagen fibrils and their structural dependence on water molecules. Secondly, we review recent evidence for the participation of proteoglycans in composing the dentin organic network. Finally, we discuss the relation of these complexly assembled nanostructures with the protease degradative processes driving the low durability of current resin-based dental restorations. We argue in favour of the structural limitations that these complexly organized and inherently hydrated organic structures may impose on the clinical prospects of current hydrophobic and hydrolyzable dental polymers that establish ultrafine contact with the tooth substrate.

Original languageEnglish (US)
Pages (from-to)2419-2433
Number of pages15
JournalActa Biomaterialia
Volume8
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

Fingerprint

Dentistry
Dentin
Synthetic Resins
Biocompatible Materials
Biomaterials
Tooth
Restoration
Substrates
Resins
Tooth Components
Proteoglycans
Stomatognathic Diseases
Collagen
Nanostructures
Polymers
Dental Caries
Durability
Peptide Hydrolases
Molecules
Water

Keywords

  • Adhesion
  • Bonding
  • Collagen
  • Dentin
  • Polymers

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology

Cite this

The dentin organic matrix - Limitations of restorative dentistry hidden on the nanometer scale. / Bertassoni, Luiz; Orgel, Joseph P R; Antipova, Olga; Swain, Michael V.

In: Acta Biomaterialia, Vol. 8, No. 7, 07.2012, p. 2419-2433.

Research output: Contribution to journalArticle

Bertassoni, Luiz ; Orgel, Joseph P R ; Antipova, Olga ; Swain, Michael V. / The dentin organic matrix - Limitations of restorative dentistry hidden on the nanometer scale. In: Acta Biomaterialia. 2012 ; Vol. 8, No. 7. pp. 2419-2433.
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