The delta opioid receptor and brain pain-modulating circuits

Mary Heinricher, Howard L. Fields

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Although it has long been recognized that the prototypic opioid analgesic morphine acts in the central nervous system to produce analgesia, the underlying mechanisms have only recently been elucidated at the level of neural circuits. Mu opioid receptors have received the most attention. Multiple lines of evidence now demonstrate that the basis for the analgesic actions of drugs acting at themuopioid receptor is recruitment of a brainstempainmodulatory network that includes the midbrain periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) [1,2]. The role of the kappa receptor in supraspinal mechanisms of pain modulation is also reasonably well understood. However, contrary to general expectations regarding the effects of opioids, activation of kappa receptors in brainstem pain modulatory circuits often exerts a functional antagonism of supraspinal mu opioid analgesia [3]. By comparison, analysis of the role of supraspinal delta receptors in pain mod-ulation is less developed. This review will consider the evidence relating to the function of the delta receptor in brainstem pain modulatory circuitry.

Original languageEnglish (US)
Title of host publicationThe Delta Receptor
PublisherCRC Press
Pages467-480
Number of pages14
ISBN (Electronic)9780203025765
ISBN (Print)9780824740313
StatePublished - Jan 1 2003

Fingerprint

delta Opioid Receptor
Pain
kappa Opioid Receptor
Brain
Analgesia
Opioid Analgesics
Brain Stem
Periaqueductal Gray
mu Opioid Receptor
Mesencephalon
Morphine
Analgesics
Central Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)
  • Health Professions(all)
  • Medicine(all)

Cite this

Heinricher, M., & Fields, H. L. (2003). The delta opioid receptor and brain pain-modulating circuits. In The Delta Receptor (pp. 467-480). CRC Press.

The delta opioid receptor and brain pain-modulating circuits. / Heinricher, Mary; Fields, Howard L.

The Delta Receptor. CRC Press, 2003. p. 467-480.

Research output: Chapter in Book/Report/Conference proceedingChapter

Heinricher, M & Fields, HL 2003, The delta opioid receptor and brain pain-modulating circuits. in The Delta Receptor. CRC Press, pp. 467-480.
Heinricher M, Fields HL. The delta opioid receptor and brain pain-modulating circuits. In The Delta Receptor. CRC Press. 2003. p. 467-480
Heinricher, Mary ; Fields, Howard L. / The delta opioid receptor and brain pain-modulating circuits. The Delta Receptor. CRC Press, 2003. pp. 467-480
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