The cyclic AMP phenotype of fragile X and autism

Daniel J. Kelley, Anita Bhattacharyya, Garet Lahvis, Jerry C P Yin, Jim Malter, Richard J. Davidson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.

Original languageEnglish (US)
Pages (from-to)1533-1543
Number of pages11
JournalNeuroscience and Biobehavioral Reviews
Volume32
Issue number8
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Autistic Disorder
Cyclic AMP
Phenotype
Anxiety
Memory Disorders
Second Messenger Systems
Intellectual Disability
Biomarkers
Therapeutics

Keywords

  • Autism
  • cAMP
  • Cyclic AMP
  • FMR1
  • FMRP
  • Fragile X
  • Signal transduction

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Kelley, D. J., Bhattacharyya, A., Lahvis, G., Yin, J. C. P., Malter, J., & Davidson, R. J. (2008). The cyclic AMP phenotype of fragile X and autism. Neuroscience and Biobehavioral Reviews, 32(8), 1533-1543. https://doi.org/10.1016/j.neubiorev.2008.06.005

The cyclic AMP phenotype of fragile X and autism. / Kelley, Daniel J.; Bhattacharyya, Anita; Lahvis, Garet; Yin, Jerry C P; Malter, Jim; Davidson, Richard J.

In: Neuroscience and Biobehavioral Reviews, Vol. 32, No. 8, 10.2008, p. 1533-1543.

Research output: Contribution to journalArticle

Kelley, DJ, Bhattacharyya, A, Lahvis, G, Yin, JCP, Malter, J & Davidson, RJ 2008, 'The cyclic AMP phenotype of fragile X and autism', Neuroscience and Biobehavioral Reviews, vol. 32, no. 8, pp. 1533-1543. https://doi.org/10.1016/j.neubiorev.2008.06.005
Kelley, Daniel J. ; Bhattacharyya, Anita ; Lahvis, Garet ; Yin, Jerry C P ; Malter, Jim ; Davidson, Richard J. / The cyclic AMP phenotype of fragile X and autism. In: Neuroscience and Biobehavioral Reviews. 2008 ; Vol. 32, No. 8. pp. 1533-1543.
@article{49e15685faee48618cb5c8b1886683c0,
title = "The cyclic AMP phenotype of fragile X and autism",
abstract = "Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.",
keywords = "Autism, cAMP, Cyclic AMP, FMR1, FMRP, Fragile X, Signal transduction",
author = "Kelley, {Daniel J.} and Anita Bhattacharyya and Garet Lahvis and Yin, {Jerry C P} and Jim Malter and Davidson, {Richard J.}",
year = "2008",
month = "10",
doi = "10.1016/j.neubiorev.2008.06.005",
language = "English (US)",
volume = "32",
pages = "1533--1543",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - The cyclic AMP phenotype of fragile X and autism

AU - Kelley, Daniel J.

AU - Bhattacharyya, Anita

AU - Lahvis, Garet

AU - Yin, Jerry C P

AU - Malter, Jim

AU - Davidson, Richard J.

PY - 2008/10

Y1 - 2008/10

N2 - Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.

AB - Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.

KW - Autism

KW - cAMP

KW - Cyclic AMP

KW - FMR1

KW - FMRP

KW - Fragile X

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=52049110500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52049110500&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2008.06.005

DO - 10.1016/j.neubiorev.2008.06.005

M3 - Article

C2 - 18601949

AN - SCOPUS:52049110500

VL - 32

SP - 1533

EP - 1543

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

IS - 8

ER -