The cyclic AMP phenotype of fragile X and autism

Daniel J. Kelley, Anita Bhattacharyya, Garet P. Lahvis, Jerry C.P. Yin, Jim Malter, Richard J. Davidson

Research output: Contribution to journalReview article

27 Scopus citations


Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.

Original languageEnglish (US)
Pages (from-to)1533-1543
Number of pages11
JournalNeuroscience and Biobehavioral Reviews
Issue number8
StatePublished - Oct 1 2008


  • Autism
  • Cyclic AMP
  • FMR1
  • FMRP
  • Fragile X
  • Signal transduction
  • cAMP

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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  • Cite this

    Kelley, D. J., Bhattacharyya, A., Lahvis, G. P., Yin, J. C. P., Malter, J., & Davidson, R. J. (2008). The cyclic AMP phenotype of fragile X and autism. Neuroscience and Biobehavioral Reviews, 32(8), 1533-1543.