The crossroads of iron with hypoxia and cellular metabolism: Implications in the pathobiology of pulmonary hypertension

Jeffrey C. Robinson, Brian B. Graham, Tracey C. Rouault, Rubin M. Tuder

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

The pathologic hallmark of pulmonary arterial hypertension (PAH) is pulmonary vascular remodeling, characterized by endothelial cell proliferation, smooth muscle hypertrophy, and perivascular inflammation, ultimately contributing to increased pulmonary arterial pressures. Several recent studies have observed that iron deficiency in patients with various forms of PAH is associated with worsened clinical outcome. Iron plays a key role in many cellular processes regulating the response to hypoxia, oxidative stress, cellular proliferation, and cell metabolism. Given the potential importance of iron supplementation in patients with the disease and the broad cellular functions of iron, we review its role in processes that pertain to PAH.

Original languageEnglish (US)
Pages (from-to)721-729
Number of pages9
JournalAmerican journal of respiratory cell and molecular biology
Volume51
Issue number6
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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