TY - JOUR
T1 - The crossroads of iron with hypoxia and cellular metabolism
T2 - Implications in the pathobiology of pulmonary hypertension
AU - Robinson, Jeffrey C.
AU - Graham, Brian B.
AU - Rouault, Tracey C.
AU - Tuder, Rubin M.
N1 - Publisher Copyright:
Copyright © 2014 by the American Thoracic Society.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The pathologic hallmark of pulmonary arterial hypertension (PAH) is pulmonary vascular remodeling, characterized by endothelial cell proliferation, smooth muscle hypertrophy, and perivascular inflammation, ultimately contributing to increased pulmonary arterial pressures. Several recent studies have observed that iron deficiency in patients with various forms of PAH is associated with worsened clinical outcome. Iron plays a key role in many cellular processes regulating the response to hypoxia, oxidative stress, cellular proliferation, and cell metabolism. Given the potential importance of iron supplementation in patients with the disease and the broad cellular functions of iron, we review its role in processes that pertain to PAH.
AB - The pathologic hallmark of pulmonary arterial hypertension (PAH) is pulmonary vascular remodeling, characterized by endothelial cell proliferation, smooth muscle hypertrophy, and perivascular inflammation, ultimately contributing to increased pulmonary arterial pressures. Several recent studies have observed that iron deficiency in patients with various forms of PAH is associated with worsened clinical outcome. Iron plays a key role in many cellular processes regulating the response to hypoxia, oxidative stress, cellular proliferation, and cell metabolism. Given the potential importance of iron supplementation in patients with the disease and the broad cellular functions of iron, we review its role in processes that pertain to PAH.
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U2 - 10.1165/rcmb.2014-0021TR
DO - 10.1165/rcmb.2014-0021TR
M3 - Review article
C2 - 24988529
AN - SCOPUS:84918776873
SN - 1044-1549
VL - 51
SP - 721
EP - 729
JO - American journal of respiratory cell and molecular biology
JF - American journal of respiratory cell and molecular biology
IS - 6
ER -