The corticotropin-releasing hormone stimulation test: A possible aid in the evaluation of patients with adrenal insufficiency

H. M. Schulte, G. P. Chrousos, P. Avgerinos, E. H. Oldfield, P. W. Gold, G. B. Cutler, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

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Abstract

Ten patients with adrenal insufficiency receiving chronic glucocorticoid therapy were studied. All had subnormal plasma cortisol responses to ovine corticotropin-releasing hormone (CRH) (1 μg/kg as an iv bolus) 12-60 h after discontinuation of steroid treatment. Plasma ACTH responses to CRH fell into three different patterns. The first 3 patients with primary adrenal insufficiency had high basal ACTH levels and augmented ACTH responses to CRH. A 4th such patient, however, treated with pharmacologic doses of prednisone, had a low normal ACTH response. Patients with secondary adrenal insufficiency had either low basal ACTH levels and diminished responses to CRH or low basal ACTH values but prolonged and augmented plasma ACTH responses to CRH with a delayed peak. We postulate that the group of patients with the former pattern have pituitary gland destruction whereas the patients with the latter pattern have hypothalamic CRH deficiency. Thus, CRH may be useful in differentiating between hypothalamic and pituitary causes of adrenal insufficiency.

Original languageEnglish (US)
Pages (from-to)1064-1067
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume58
Issue number6
StatePublished - 1984
Externally publishedYes

Fingerprint

Adrenal Insufficiency
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Plasmas
Pituitary Hormone-Releasing Hormones
Addison Disease
Pituitary Gland
Prednisone
Glucocorticoids
Hydrocortisone
Sheep
Steroids
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The corticotropin-releasing hormone stimulation test : A possible aid in the evaluation of patients with adrenal insufficiency. / Schulte, H. M.; Chrousos, G. P.; Avgerinos, P.; Oldfield, E. H.; Gold, P. W.; Cutler, G. B.; Loriaux, Donald (Lynn).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 58, No. 6, 1984, p. 1064-1067.

Research output: Contribution to journalArticle

Schulte, H. M. ; Chrousos, G. P. ; Avgerinos, P. ; Oldfield, E. H. ; Gold, P. W. ; Cutler, G. B. ; Loriaux, Donald (Lynn). / The corticotropin-releasing hormone stimulation test : A possible aid in the evaluation of patients with adrenal insufficiency. In: Journal of Clinical Endocrinology and Metabolism. 1984 ; Vol. 58, No. 6. pp. 1064-1067.
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