The continuum of growth hormone-IGF-I axis defects causing short stature: Diagnostic and therapeutic challenges

Martin O. Savage, Christine P. Burren, Ron G. Rosenfeld

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

The growth hormone (GH)-IGF-I axis is essential for normal foetal and childhood growth. Defects at different sites in the axis frequently result in short stature which may compromise adult height. We describe a continuum of clinically relevant abnormalities from GH deficiency through to GH resistance and discuss the implementation and interpretation of investigations. We consider appropriate therapy for patients with abnormal auxology and subnormal adult height prognosis, highlighting new data to clarify therapeutic choices leading to optimal clinical outcome.

Original languageEnglish (US)
Pages (from-to)721-728
Number of pages8
JournalClinical Endocrinology
Volume72
Issue number6
DOIs
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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