The COMT val158met polymorphism is associated with prevalent fractures in Swedish men

Anna L. Eriksson, Dan Mellström, Mattias Lorentzon, Eric Orwoll, Inga Redlund-Johnell, Elin Grundberg, Anna Holmberg, Östen Ljunggren, Magnus K. Karlsson, Claes Ohlsson

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Abstract

Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of ≥ 1 fracture was 37.2% in COMTLL, 35.7% in COMTHL and 30.4% in COMTHH (p <0.05). Early fractures (≤ 50 years of age) were less common in COMTHH than in the combined COMTLL + HL genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMTHH compared with COMTLL + HL was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalBone
Volume42
Issue number1
DOIs
StatePublished - Jan 2008

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Catechol O-Methyltransferase
Bone Density
Skeleton
Bone Fractures
Enzymes
Estrogens
Steroids
Genotype
Maintenance
Growth
Population

Keywords

  • COMT
  • Estrogen
  • Fracture
  • Men
  • Polymorphism

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

Eriksson, A. L., Mellström, D., Lorentzon, M., Orwoll, E., Redlund-Johnell, I., Grundberg, E., ... Ohlsson, C. (2008). The COMT val158met polymorphism is associated with prevalent fractures in Swedish men. Bone, 42(1), 107-112. https://doi.org/10.1016/j.bone.2007.08.045

The COMT val158met polymorphism is associated with prevalent fractures in Swedish men. / Eriksson, Anna L.; Mellström, Dan; Lorentzon, Mattias; Orwoll, Eric; Redlund-Johnell, Inga; Grundberg, Elin; Holmberg, Anna; Ljunggren, Östen; Karlsson, Magnus K.; Ohlsson, Claes.

In: Bone, Vol. 42, No. 1, 01.2008, p. 107-112.

Research output: Contribution to journalArticle

Eriksson, AL, Mellström, D, Lorentzon, M, Orwoll, E, Redlund-Johnell, I, Grundberg, E, Holmberg, A, Ljunggren, Ö, Karlsson, MK & Ohlsson, C 2008, 'The COMT val158met polymorphism is associated with prevalent fractures in Swedish men', Bone, vol. 42, no. 1, pp. 107-112. https://doi.org/10.1016/j.bone.2007.08.045
Eriksson AL, Mellström D, Lorentzon M, Orwoll E, Redlund-Johnell I, Grundberg E et al. The COMT val158met polymorphism is associated with prevalent fractures in Swedish men. Bone. 2008 Jan;42(1):107-112. https://doi.org/10.1016/j.bone.2007.08.045
Eriksson, Anna L. ; Mellström, Dan ; Lorentzon, Mattias ; Orwoll, Eric ; Redlund-Johnell, Inga ; Grundberg, Elin ; Holmberg, Anna ; Ljunggren, Östen ; Karlsson, Magnus K. ; Ohlsson, Claes. / The COMT val158met polymorphism is associated with prevalent fractures in Swedish men. In: Bone. 2008 ; Vol. 42, No. 1. pp. 107-112.
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abstract = "Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75{\%} difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0{\%}). Prevalence of ≥ 1 fracture was 37.2{\%} in COMTLL, 35.7{\%} in COMTHL and 30.4{\%} in COMTHH (p <0.05). Early fractures (≤ 50 years of age) were less common in COMTHH than in the combined COMTLL + HL genotype, OR 0.78 (95{\%} CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMTHH compared with COMTLL + HL was 0.74 (95{\%} CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).",
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T1 - The COMT val158met polymorphism is associated with prevalent fractures in Swedish men

AU - Eriksson, Anna L.

AU - Mellström, Dan

AU - Lorentzon, Mattias

AU - Orwoll, Eric

AU - Redlund-Johnell, Inga

AU - Grundberg, Elin

AU - Holmberg, Anna

AU - Ljunggren, Östen

AU - Karlsson, Magnus K.

AU - Ohlsson, Claes

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N2 - Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of ≥ 1 fracture was 37.2% in COMTLL, 35.7% in COMTHL and 30.4% in COMTHH (p <0.05). Early fractures (≤ 50 years of age) were less common in COMTHH than in the combined COMTLL + HL genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMTHH compared with COMTLL + HL was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).

AB - Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of ≥ 1 fracture was 37.2% in COMTLL, 35.7% in COMTHL and 30.4% in COMTHH (p <0.05). Early fractures (≤ 50 years of age) were less common in COMTHH than in the combined COMTLL + HL genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMTHH compared with COMTLL + HL was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).

KW - COMT

KW - Estrogen

KW - Fracture

KW - Men

KW - Polymorphism

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