The COMT val158met polymorphism is associated with prevalent fractures in Swedish men

Anna L. Eriksson; Dan Mellström; Mattias Lorentzon; Eric S. Orwoll; Inga Redlund-Johnell; Elin Grundberg; Anna Holmberg; Östen Ljunggren; Magnus K. Karlsson; Claes Ohlsson

doi:10.1016/j.bone.2007.08.045

The COMT val158met polymorphism is associated with prevalent fractures in Swedish men

Anna L. Eriksson, Dan Mellström, Mattias Lorentzon, Eric S. Orwoll, Inga Redlund-Johnell, Elin Grundberg, Anna Holmberg, Östen Ljunggren, Magnus K. Karlsson, Claes Ohlsson

Endocrinology, Diabetes and Clinical Nutrition

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of ≥ 1 fracture was 37.2% in COMT^LL, 35.7% in COMT^HL and 30.4% in COMT^HH (p < 0.05). Early fractures (≤ 50 years of age) were less common in COMT^HH than in the combined COMT^{LL + HL} genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMT^HH compared with COMT^{LL + HL} was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).

Original language	English (US)
Pages (from-to)	107-112
Number of pages	6
Journal	Bone
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.bone.2007.08.045
State	Published - Jan 2008

Keywords

COMT
Estrogen
Fracture
Men
Polymorphism

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Physiology
Histology

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10.1016/j.bone.2007.08.045

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@article{98cc2389dbf24422823169a974477ba2,

title = "The COMT val158met polymorphism is associated with prevalent fractures in Swedish men",

abstract = "Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of ≥ 1 fracture was 37.2% in COMTLL, 35.7% in COMTHL and 30.4% in COMTHH (p < 0.05). Early fractures (≤ 50 years of age) were less common in COMTHH than in the combined COMTLL + HL genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMTHH compared with COMTLL + HL was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).",

keywords = "COMT, Estrogen, Fracture, Men, Polymorphism",

author = "Eriksson, {Anna L.} and Dan Mellstr{\"o}m and Mattias Lorentzon and Orwoll, {Eric S.} and Inga Redlund-Johnell and Elin Grundberg and Anna Holmberg and {\"O}sten Ljunggren and Karlsson, {Magnus K.} and Claes Ohlsson",

note = "Funding Information: Funding: This study was supported by the Swedish Research Council, the Swedish Foundation for Strategic Research, European Commission Grant QLK4-CT-2002-02528, The ALF/LUA research grant in G{\"o}teborg, the Lundberg Foundation, the Torsten and Ragnar S{\"o}derberg's Foundation, Petrus and Augusta Hedlunds Foundation, the Novo Nordisk Foundation and The G{\"o}teborg Medical Society. ",

year = "2008",

month = jan,

doi = "10.1016/j.bone.2007.08.045",

language = "English (US)",

volume = "42",

pages = "107--112",

journal = "Bone",

issn = "8756-3282",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - The COMT val158met polymorphism is associated with prevalent fractures in Swedish men

AU - Eriksson, Anna L.

AU - Mellström, Dan

AU - Lorentzon, Mattias

AU - Orwoll, Eric S.

AU - Redlund-Johnell, Inga

AU - Grundberg, Elin

AU - Holmberg, Anna

AU - Ljunggren, Östen

AU - Karlsson, Magnus K.

AU - Ohlsson, Claes

N1 - Funding Information: Funding: This study was supported by the Swedish Research Council, the Swedish Foundation for Strategic Research, European Commission Grant QLK4-CT-2002-02528, The ALF/LUA research grant in Göteborg, the Lundberg Foundation, the Torsten and Ragnar Söderberg's Foundation, Petrus and Augusta Hedlunds Foundation, the Novo Nordisk Foundation and The Göteborg Medical Society.

PY - 2008/1

Y1 - 2008/1

N2 - Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of ≥ 1 fracture was 37.2% in COMTLL, 35.7% in COMTHL and 30.4% in COMTHH (p < 0.05). Early fractures (≤ 50 years of age) were less common in COMTHH than in the combined COMTLL + HL genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMTHH compared with COMTLL + HL was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).

AB - Introduction: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. Methods: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. Results: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of ≥ 1 fracture was 37.2% in COMTLL, 35.7% in COMTHL and 30.4% in COMTHH (p < 0.05). Early fractures (≤ 50 years of age) were less common in COMTHH than in the combined COMTLL + HL genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (> 50 years of age). The OR for fracture of the non-weight bearing skeleton in COMTHH compared with COMTLL + HL was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. Conclusions: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (≤ 50 years of age).

KW - COMT

KW - Estrogen

KW - Fracture

KW - Men

KW - Polymorphism

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DO - 10.1016/j.bone.2007.08.045

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SP - 107

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JO - Bone

JF - Bone

IS - 1

ER -

The COMT val158met polymorphism is associated with prevalent fractures in Swedish men

Abstract

Keywords

ASJC Scopus subject areas

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