The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats

Salmon oil versus vegetable oils

William Harris, William E. Connor, Martha P. McMurry

Research output: Contribution to journalArticle

295 Citations (Scopus)

Abstract

The lower plasma lipid levels and lower incidence of atherosclerotic diseases in Greenland Eskimos suggested that the unusual fatty acids present in their diet of seal and fish may be anti-atherogenic. These fatty acids are eicosapentaenoic (C20:5) and docosahexaenoic (C22:6) acids and are of the omega-3 fatty acid family. We have compared a salmon oil diet containing high levels of these unique fatty acids to a control diet high in saturated fat and to a vegetable oil diet high in linoleic acid (C18:2). All diets contained 40% of the total calories as fat and 500 mg of cholesterol; they differed only in fatty acid composition. In 4 wk the salmon oil diet reduced plasma cholesterol levels from 188 to 162 mg/dl (p <0.001) and triglyceride levels from 77 to 48 mg/dl (p <0.005). LDL and VLDL cholesterol levels changed from 128 to 108 and 13 to 8 mg/dl (p <0.005), respectively. HDL cholesterol levels did not change. The vegetable oil diet caused similar decreases in cholesterol levels but did not lower triglyceride levels. The omega-3 fatty acids comprised up to 30% of the total fatty acids in each plasma lipid class after the salmon diet. Fish oils contain fatty acids which may be metabolically unique and potentially useful in the control of both hypercholesterolemia and hypertriglyceridemia.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalMetabolism
Volume32
Issue number2
DOIs
StatePublished - 1983

Fingerprint

Plant Oils
Dietary Fats
Lipoproteins
Diet
Lipids
Fatty Acids
Cholesterol
Omega-3 Fatty Acids
Triglycerides
Fats
Inuits
Greenland
VLDL Cholesterol
salmon oil
Fish Oils
Hypertriglyceridemia
Salmon
Linoleic Acid
Hypercholesterolemia
LDL Cholesterol

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats : Salmon oil versus vegetable oils. / Harris, William; Connor, William E.; McMurry, Martha P.

In: Metabolism, Vol. 32, No. 2, 1983, p. 179-184.

Research output: Contribution to journalArticle

Harris, William ; Connor, William E. ; McMurry, Martha P. / The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats : Salmon oil versus vegetable oils. In: Metabolism. 1983 ; Vol. 32, No. 2. pp. 179-184.
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