The coming of age of radiation-induced hyperparathyroidism: Evolving patterns of thyroid and parathyroid disease after head and neck irradiation

Antonia E. Stephen, Kathryn T. Chen, Kresimira Milas, Allan E. Siperstein

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Abstract

This study investigates the association of thyroid and parathyroid disease in radiation-exposed patients and tests the hypothesis that hyperparathyroidism (HPT) occurs after a longer latency period. Routine questioning identified 40 patients in the endocrine surgery clinic with a history of radiation exposure. Patients with thyroid disease were screened for HPT and vice versa. The known diagnosis at initial referral was thyroid disease alone in 26 of 40 patients, HPT alone in 9 of 40 patients, and both in 5 of 40 patients. After screening was completed, a total of 18 of 40 patients were found to have both thyroid disease and HPT. HPT manifested an average of 17 years later than thyroid disease (52.6 ± 10.0 years vs 35.5 ± 13.8 years after radiation therapy [P

Original languageEnglish (US)
Pages (from-to)1143-1153
Number of pages11
JournalSurgery
Volume136
Issue number6
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

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