TY - JOUR
T1 - The Clinical Value of Negative Temporal Artery Biopsy Specimens
AU - Hedges, Thomas R.
AU - Gieger, Greer L.
AU - Albert, Daniel M.
PY - 1983/8
Y1 - 1983/8
N2 - The clinical course of patients with signs and symptoms suggestive of temporal artertis but with negative temporal artery biopsy specimens was evaluated. Ninety-one patients undergoing a biopsy formed the basis of this study. Of these, 63 patients had no evidence of arteritis on biopsy, and 28 patients had biopsy specimens showing granulomatous inflammation. False-negative findings from biopsy specimens occurred in 5% of patients who had the disease. Cancer was the final diagnosis in 21% of patients with negative biopsy specimens v3% of patients with temporal arteritis. Various chronic systemic inflammatory diseases were found in 16% of patients with negative biopsy specimens, while none of the patients with temporal arteritis had additional systemic inflammatory diseases. Patients with proven arteritis were notably older and had higher ESRs than patients without the disease. However, no laboratory test or frequently observed symptom or sign noted on initial examination, considered alone or in combination with other findings, had diagnostic sensitivity or specificity as high as temporal artery biopsy.
AB - The clinical course of patients with signs and symptoms suggestive of temporal artertis but with negative temporal artery biopsy specimens was evaluated. Ninety-one patients undergoing a biopsy formed the basis of this study. Of these, 63 patients had no evidence of arteritis on biopsy, and 28 patients had biopsy specimens showing granulomatous inflammation. False-negative findings from biopsy specimens occurred in 5% of patients who had the disease. Cancer was the final diagnosis in 21% of patients with negative biopsy specimens v3% of patients with temporal arteritis. Various chronic systemic inflammatory diseases were found in 16% of patients with negative biopsy specimens, while none of the patients with temporal arteritis had additional systemic inflammatory diseases. Patients with proven arteritis were notably older and had higher ESRs than patients without the disease. However, no laboratory test or frequently observed symptom or sign noted on initial examination, considered alone or in combination with other findings, had diagnostic sensitivity or specificity as high as temporal artery biopsy.
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U2 - 10.1001/archopht.1983.01040020253019
DO - 10.1001/archopht.1983.01040020253019
M3 - Article
C2 - 6882256
AN - SCOPUS:0020558914
SN - 0003-9950
VL - 101
SP - 1251
EP - 1254
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 8
ER -