The clinical spectrum of schwannomas presenting with visual dysfunction: A clinicopathologic study of three cases

Kimberly Peele Cockerham, Glenn C. Cockerham, Richard Stutzman, Ahmed A. Hidayat, Mark H. Depper, Roger E. Turbin, John S. Kennerdell

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Schwannomas (neurilemomas) are benign tumors that arise from Schwann cells in the peripheral nervous system. The most commonly involved nerves that cause neuro-ophthalmic manifestations are cranial nerves V and VIII. In this series of three women, schwannomas presented as intraconal masses that mimicked a cavernous hemangioma, a superior orbital mass transgressing the superior orbital fissure, and an expansive frontal lobe mass with clinical symptoms and signs of increased intracranial pressure. Although all three complained of visual blurring, none of our patients presented with Vth or VIIIth cranial nerve dysfunction. Histopathologic studies demonstrated well-circumscribed, encapsulated spindle-cell lesions with classic Antoni A and B patterns. Histopathologic examination is essential to confirm the diagnosis of a schwannoma that may be otherwise clinically confusing. Direct optic nerve compression, globe indentation with induced hyperopia, or increased intracranial pressure with optic nerve compromise may be responsible for visual symptoms. A multidisciplinary approach is often required because of the size and location of schwannomas. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)226-234
Number of pages9
JournalSurvey of Ophthalmology
Volume44
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Neurilemoma
  • Schwannoma
  • Tumor

ASJC Scopus subject areas

  • Ophthalmology

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    Cockerham, K. P., Cockerham, G. C., Stutzman, R., Hidayat, A. A., Depper, M. H., Turbin, R. E., & Kennerdell, J. S. (1999). The clinical spectrum of schwannomas presenting with visual dysfunction: A clinicopathologic study of three cases. Survey of Ophthalmology, 44(3), 226-234. https://doi.org/10.1016/S0039-6257(99)00100-9