The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats

Kun Hu, Frank A.J.L. Scheer, Ruud M. Buijs, Steven A. Shea

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Aims: Adverse cardiovascular events in humans occur with a day/night pattern, presumably related to a daily pattern of behaviours or endogenous circadian rhythms in cardiovascular variables. Healthy humans possess a scale-invariant/fractal structure in heartbeat fluctuations that exhibits an endogenous circadian rhythm and changes towards the structure observed in cardiovascular disease at the circadian phase corresponding to the time of the broad peak of adverse cardiovascular events (at about 10 AM). To explore the relationship between the rest/activity cycle, endogenous circadian rhythmicity, and cardiac vulnerability, we tested whether the fractal structure of heart rate exhibits a similar circadian rhythm in a mammalian species that is nocturnally active (Wistar rats) compared with diurnally active humans, and how this fractal structure changes after lesioning the circadian pacemaker (suprachiasmatic nucleus, SCN) in rats. Methods and results: Analysis of heart rate data collected over 10 days in eight intact and six SCN-lesioned Wistar rats during constant darkness revealed that: (i) as with humans, rats exhibit an endogenous circadian rhythm in the scaling exponent characterizing the hourly fractal structure of heart rate (P = 0.0005) with larger exponents during the biological day (inactive phase for rats; active phase for humans); (ii) SCN lesioning abolished the rhythm in the fractal structure of heart rate and systematically increased the scaling exponent (P = 0.01). Conclusion: Rats possess a circadian rhythm of fractal structure of heart rate with a similar temporal pattern as previously observed in humans despite opposite rest/activity cycles between the two species. The SCN imparts this endogenous rhythm. Moreover, lesioning the SCN in rats results in a larger scaling exponent, as occurs with cardiovascular disease in humans.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalCardiovascular research
Issue number1
StatePublished - Oct 2008
Externally publishedYes


  • Behaviour
  • Cardiac vulnerability
  • Circadian rhythms
  • Heart rate control
  • Rest/activity cycle
  • Scale-invariant/fractal structure
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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