The Chemical Biology of Phosphoinositide 3-Kinases

Matthias P. Wymann, Carsten Schultz

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Since its discovery in the late 1980s, phosphoinositide 3-kinase (PI3K), and its isoforms have arguably reached the forefront of signal transduction research. Regulation of this lipid kinase, its functions, its effectors, in short its entire signaling network, has been extensively studied. PI3K inhibitors are frequently used in biochemistry and cell biology. In addition, many pharmaceutical companies have launched drug-discovery programs to identify modulators of PI3Ks. Despite these efforts and a fairly good knowledge of the PI3K signaling network, we still have only a rudimentary picture of the signaling dynamics of PI3K and its lipid products in space and time. It is therefore essential to create and use novel biological and chemical tools to manipulate the phosphoinositide signaling network with spatial and temporal resolution. In this review, we discuss the current and potential future tools that are available and necessary to unravel the various functions of PI3K and its isoforms.

Original languageEnglish (US)
Pages (from-to)2022-2035
Number of pages14
JournalChemBioChem
Volume13
Issue number14
DOIs
StatePublished - Sep 24 2012

Keywords

  • PI3K inhibitors
  • Phosphoinositide 3-kinase
  • Rapamycin
  • Signaling pathways
  • Wortmannin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'The Chemical Biology of Phosphoinositide 3-Kinases'. Together they form a unique fingerprint.

  • Cite this