The changing spectrum of hypertension in premature infants

Research output: Contribution to journalArticle

Abstract

Objective: The objective is to document changes in the etiologic spectrum of hypertension in premature infants. Study design: We reviewed all cases of systemic hypertension (HTN) in premature infants at two centers over 8 years. Infants were sorted into categorical groups as described in 2012 by Flynn. Analyses included frequency of diagnosis, timecourse of HTN, and diagnostics. Phthalate exposure via intravenous fluid and respiratory equipment was compared among groups and centers. Results: One hundred and twenty-nine infants having 130 episodes of HTN met the inclusion criteria. Sixty-five percent of cases were classified as pulmonary and 16% as miscellaneous. Plasma renin activity (PRA) was undetectable or <11 ng/mL/h in almost all hypertensive infants. Cases categorized as Pulmonary, medications/intoxications, and miscellaneous presented near 40 weeks postmenstrual age, with low PRA and large phthalate exposures. Conclusions: High PRA HTN has been replaced by low PRA in most cases, and may be due to phthalate exposure.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Jan 1 2019

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Premature Infants
Renin
Hypertension
Lung
Equipment and Supplies
phthalic acid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

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title = "The changing spectrum of hypertension in premature infants",
abstract = "Objective: The objective is to document changes in the etiologic spectrum of hypertension in premature infants. Study design: We reviewed all cases of systemic hypertension (HTN) in premature infants at two centers over 8 years. Infants were sorted into categorical groups as described in 2012 by Flynn. Analyses included frequency of diagnosis, timecourse of HTN, and diagnostics. Phthalate exposure via intravenous fluid and respiratory equipment was compared among groups and centers. Results: One hundred and twenty-nine infants having 130 episodes of HTN met the inclusion criteria. Sixty-five percent of cases were classified as pulmonary and 16{\%} as miscellaneous. Plasma renin activity (PRA) was undetectable or <11 ng/mL/h in almost all hypertensive infants. Cases categorized as Pulmonary, medications/intoxications, and miscellaneous presented near 40 weeks postmenstrual age, with low PRA and large phthalate exposures. Conclusions: High PRA HTN has been replaced by low PRA in most cases, and may be due to phthalate exposure.",
author = "K. Farnbach and Sandra Iragorri and Amira Al-Uzri and David Rozansky and R. Forbush and Randall Jenkins",
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T1 - The changing spectrum of hypertension in premature infants

AU - Farnbach, K.

AU - Iragorri, Sandra

AU - Al-Uzri, Amira

AU - Rozansky, David

AU - Forbush, R.

AU - Jenkins, Randall

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: The objective is to document changes in the etiologic spectrum of hypertension in premature infants. Study design: We reviewed all cases of systemic hypertension (HTN) in premature infants at two centers over 8 years. Infants were sorted into categorical groups as described in 2012 by Flynn. Analyses included frequency of diagnosis, timecourse of HTN, and diagnostics. Phthalate exposure via intravenous fluid and respiratory equipment was compared among groups and centers. Results: One hundred and twenty-nine infants having 130 episodes of HTN met the inclusion criteria. Sixty-five percent of cases were classified as pulmonary and 16% as miscellaneous. Plasma renin activity (PRA) was undetectable or <11 ng/mL/h in almost all hypertensive infants. Cases categorized as Pulmonary, medications/intoxications, and miscellaneous presented near 40 weeks postmenstrual age, with low PRA and large phthalate exposures. Conclusions: High PRA HTN has been replaced by low PRA in most cases, and may be due to phthalate exposure.

AB - Objective: The objective is to document changes in the etiologic spectrum of hypertension in premature infants. Study design: We reviewed all cases of systemic hypertension (HTN) in premature infants at two centers over 8 years. Infants were sorted into categorical groups as described in 2012 by Flynn. Analyses included frequency of diagnosis, timecourse of HTN, and diagnostics. Phthalate exposure via intravenous fluid and respiratory equipment was compared among groups and centers. Results: One hundred and twenty-nine infants having 130 episodes of HTN met the inclusion criteria. Sixty-five percent of cases were classified as pulmonary and 16% as miscellaneous. Plasma renin activity (PRA) was undetectable or <11 ng/mL/h in almost all hypertensive infants. Cases categorized as Pulmonary, medications/intoxications, and miscellaneous presented near 40 weeks postmenstrual age, with low PRA and large phthalate exposures. Conclusions: High PRA HTN has been replaced by low PRA in most cases, and may be due to phthalate exposure.

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