TY - JOUR
T1 - The Changing Liver Transplant Recipient
T2 - From Hepatitis C to Nonalcoholic Steatohepatitis and Alcohol
AU - Vyhmeister, Ross
AU - Enestvedt, C. Kristian
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/2
Y1 - 2021/2
N2 - Hepatitis C virus has historically been the leading indication for liver transplant, followed by nonalcoholic steatohepatitis (NASH) and alcoholic liver disease. Severe alcoholic hepatitis has become a growing indication for liver transplant, and overall alcohol use rates continue to increase in the United States. Rates of obesity and NASH in the United States continue to increase and are expected to place increasing demand on liver transplant infrastructure. In the current absence of robust pharmacologic therapy for NASH, the use of bariatric procedures and surgeries is being explored, as are other innovative approaches to curtail this upward trend.
AB - Hepatitis C virus has historically been the leading indication for liver transplant, followed by nonalcoholic steatohepatitis (NASH) and alcoholic liver disease. Severe alcoholic hepatitis has become a growing indication for liver transplant, and overall alcohol use rates continue to increase in the United States. Rates of obesity and NASH in the United States continue to increase and are expected to place increasing demand on liver transplant infrastructure. In the current absence of robust pharmacologic therapy for NASH, the use of bariatric procedures and surgeries is being explored, as are other innovative approaches to curtail this upward trend.
KW - Alcoholic liver disease
KW - Hepatitis C
KW - Indications
KW - Liver transplant
KW - Nonalcoholic steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=85096666841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096666841&partnerID=8YFLogxK
U2 - 10.1016/j.cld.2020.08.012
DO - 10.1016/j.cld.2020.08.012
M3 - Review article
C2 - 33978575
AN - SCOPUS:85096666841
SN - 1089-3261
VL - 25
SP - 137
EP - 155
JO - Clinics in liver disease
JF - Clinics in liver disease
IS - 1
ER -