The CEPH consortium linkage map of human chromosome 11

M. Litt; P. Kramer; E. Kort; P. Fain; S. Cox; D. Root; R. White; J. Weissenbach; H. Donis-Keller; R. Gatti; J. Weber; Y. Nakamura; C. Julier; K. Hayashi; N. Spurr; M. Dean; J. Mandel; K. Kidd; T. Kruse; A. Retief; A. Bale; T. Meo; G. Vergnaud; S. Warren; H. F. Willard

doi:10.1006/geno.1995.1011

The CEPH consortium linkage map of human chromosome 11

M. Litt, P. Kramer, E. Kort, P. Fain, S. Cox, D. Root, R. White, J. Weissenbach, H. Donis-Keller, R. Gatti, J. Weber, Y. Nakamura, C. Julier, K. Hayashi, N. Spurr, M. Dean, J. Mandel, K. Kidd, T. Kruse, A. RetiefA. Bale, T. Meo, G. Vergnaud, S. Warren, H. F. Willard

Neurology

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Abstract

The CEPH consortium framework map of chromosome 11 is presented. The map was generated from CEPH family DNAs with 181 probe/enzyme combinations contributed by 20 laboratories. Seventy-seven of the loci are defined by microsatellite polymorphisms that can be typed by the PCR. A total of 42 loci have been placed on the map with likelihood support of at least 1000:1. The female, male, and sex-average maps extend for 179.6, 110.8, and 145.3 cM, respectively. The largest interval on the sex-average map is less than 11 cM, and the average distance between uniquely placed loci is 4 cM. The genotypic data obtained for map construction have been used to identify the positions of crossovers on the chromosomes of CEPH family children, allowing the localization of new markers without computationally intensive likelihood models and providing a basis for efficient extension of the linkage map to higher resolution.

Original language	English (US)
Pages (from-to)	101-112
Number of pages	12
Journal	Genomics
Volume	27
Issue number	1
DOIs	https://doi.org/10.1006/geno.1995.1011
State	Published - May 1 1995

ASJC Scopus subject areas

Genetics

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Litt, M, Kramer, P, Kort, E, Fain, P, Cox, S, Root, D, White, R, Weissenbach, J, Donis-Keller, H, Gatti, R, Weber, J, Nakamura, Y, Julier, C, Hayashi, K, Spurr, N, Dean, M, Mandel, J, Kidd, K, Kruse, T, Retief, A, Bale, A, Meo, T, Vergnaud, G, Warren, S & Willard, HF 1995, 'The CEPH consortium linkage map of human chromosome 11', Genomics, vol. 27, no. 1, pp. 101-112. https://doi.org/10.1006/geno.1995.1011

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abstract = "The CEPH consortium framework map of chromosome 11 is presented. The map was generated from CEPH family DNAs with 181 probe/enzyme combinations contributed by 20 laboratories. Seventy-seven of the loci are defined by microsatellite polymorphisms that can be typed by the PCR. A total of 42 loci have been placed on the map with likelihood support of at least 1000:1. The female, male, and sex-average maps extend for 179.6, 110.8, and 145.3 cM, respectively. The largest interval on the sex-average map is less than 11 cM, and the average distance between uniquely placed loci is 4 cM. The genotypic data obtained for map construction have been used to identify the positions of crossovers on the chromosomes of CEPH family children, allowing the localization of new markers without computationally intensive likelihood models and providing a basis for efficient extension of the linkage map to higher resolution.",

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AU - Kort, E.

AU - Fain, P.

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AU - Root, D.

AU - White, R.

AU - Weissenbach, J.

AU - Donis-Keller, H.

AU - Gatti, R.

AU - Weber, J.

AU - Nakamura, Y.

AU - Julier, C.

AU - Hayashi, K.

AU - Spurr, N.

AU - Dean, M.

AU - Mandel, J.

AU - Kidd, K.

AU - Kruse, T.

AU - Retief, A.

AU - Bale, A.

AU - Meo, T.

AU - Vergnaud, G.

AU - Warren, S.

AU - Willard, H. F.

PY - 1995/5/1

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N2 - The CEPH consortium framework map of chromosome 11 is presented. The map was generated from CEPH family DNAs with 181 probe/enzyme combinations contributed by 20 laboratories. Seventy-seven of the loci are defined by microsatellite polymorphisms that can be typed by the PCR. A total of 42 loci have been placed on the map with likelihood support of at least 1000:1. The female, male, and sex-average maps extend for 179.6, 110.8, and 145.3 cM, respectively. The largest interval on the sex-average map is less than 11 cM, and the average distance between uniquely placed loci is 4 cM. The genotypic data obtained for map construction have been used to identify the positions of crossovers on the chromosomes of CEPH family children, allowing the localization of new markers without computationally intensive likelihood models and providing a basis for efficient extension of the linkage map to higher resolution.

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The CEPH consortium linkage map of human chromosome 11

Abstract

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