The cellular mechanisms that maintain neuronal polarity

Marvin Bentley, Gary Banker

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

As polarized cells, neurons maintain different sets of resident plasma membrane proteins in their axons and dendrites, which is consistent with the different roles that these neurites have in electrochemical signalling. Axonal and dendritic proteins are synthesized together within the somatodendritic domain; this raises a fundamental question: what is the nature of the intracellular trafficking machinery that ensures that these proteins reach the correct domain? Recent studies have advanced our understanding of the processes underlying the selective sorting and selective transport of axonal and dendritic proteins and have created potential avenues for future progress.

Original languageEnglish (US)
JournalNature Reviews Neuroscience
DOIs
StateAccepted/In press - Aug 11 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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