The cell biology and physiologic relevance of ApoE recycling

Sergio Fazio, MacRae F. Linton, Larry L. Swift

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Apolipoprotein E (apoE) is unique among the different apoproteins because of its many functions in the assembly, processing, and removal of plasma lipoproteins. Some of these functions require the presence of apoE inside the cell or in close association with its outer membrane. For example, the presence of apoE increases triglyceride content in newly formed very low-density lipoprotein (VLDL), whereas the fast removal of chylomicrons requires the presence of a cellular pool of apoE ready to surface and bind to membrane proteoglycans and possibly to lipoprotein receptors such as the LDL receptor-related protein (LRP). Our recent discovery that VLDL-apoE internalized by hepatocytes is partially protected from lysosomal degradation and recycles through the Golgi apparatus suggests that the biologic cycle of apoE may not be concluded when the lipoprotein is taken up by the cell, and that recycling apoE may have a physiologic role in lipoprotein assembly, remnant removal, and cholesterol efflux.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalTrends in Cardiovascular Medicine
Volume10
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

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Recycling
Apolipoproteins E
Cell Biology
Lipoproteins
VLDL Lipoproteins
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Chylomicrons
Apoproteins
Membranes
Golgi Apparatus
Proteoglycans
Hepatocytes
Triglycerides
Cholesterol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The cell biology and physiologic relevance of ApoE recycling. / Fazio, Sergio; Linton, MacRae F.; Swift, Larry L.

In: Trends in Cardiovascular Medicine, Vol. 10, No. 1, 2000, p. 23-30.

Research output: Contribution to journalArticle

Fazio, Sergio ; Linton, MacRae F. ; Swift, Larry L. / The cell biology and physiologic relevance of ApoE recycling. In: Trends in Cardiovascular Medicine. 2000 ; Vol. 10, No. 1. pp. 23-30.
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