The caudal ventrolateral medulla is a source of tonic sympathoinhibition

S. L. Cravo, Shaun Morrison

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Abstract

The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. The sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalBrain Research
Volume621
Issue number1
DOIs
Publication statusPublished - Sep 3 1993
Externally publishedYes

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Keywords

  • Baroreceptor reflex
  • Blood pressure regulation
  • Sympathetic nerve activity
  • Ventrolateral medulla

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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