The caudal ventrolateral medulla is a source of tonic sympathoinhibition

S. L. Cravo; S. F. Morrison

doi:10.1016/0006-8993(93)90308-A

The caudal ventrolateral medulla is a source of tonic sympathoinhibition

S. L. Cravo, S. F. Morrison

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. The sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.

Original language	English (US)
Pages (from-to)	133-136
Number of pages	4
Journal	Brain research
Volume	621
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)90308-A
State	Published - Sep 3 1993
Externally published	Yes

Keywords

Baroreceptor reflex
Blood pressure regulation
Sympathetic nerve activity
Ventrolateral medulla

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90308-A

Cite this

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title = "The caudal ventrolateral medulla is a source of tonic sympathoinhibition",

abstract = "The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. The sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.",

keywords = "Baroreceptor reflex, Blood pressure regulation, Sympathetic nerve activity, Ventrolateral medulla",

author = "Cravo, {S. L.} and Morrison, {S. F.}",

note = "Funding Information: This work was supported by National Heart, Lung, and Blood Institute Grant HL-18974 and Sao Paulo State Research Foundation (FAPESP) Grant 90/1943-2. A portion was completed at Division of Neurobiology,C ornell University Medical College (Director: D.J. Reis). We thank C. Young-Polchowf or photography.",

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doi = "10.1016/0006-8993(93)90308-A",

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volume = "621",

pages = "133--136",

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T1 - The caudal ventrolateral medulla is a source of tonic sympathoinhibition

AU - Cravo, S. L.

AU - Morrison, S. F.

N1 - Funding Information: This work was supported by National Heart, Lung, and Blood Institute Grant HL-18974 and Sao Paulo State Research Foundation (FAPESP) Grant 90/1943-2. A portion was completed at Division of Neurobiology,C ornell University Medical College (Director: D.J. Reis). We thank C. Young-Polchowf or photography.

PY - 1993/9/3

Y1 - 1993/9/3

N2 - The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. The sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.

AB - The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. The sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.

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KW - Blood pressure regulation

KW - Sympathetic nerve activity

KW - Ventrolateral medulla

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The caudal ventrolateral medulla is a source of tonic sympathoinhibition

Abstract

Keywords

ASJC Scopus subject areas

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