The caudal ventrolateral medulla is a source of tonic sympathoinhibition

S. L. Cravo, S. F. Morrison

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. The sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalBrain research
Volume621
Issue number1
DOIs
StatePublished - Sep 3 1993
Externally publishedYes

Keywords

  • Baroreceptor reflex
  • Blood pressure regulation
  • Sympathetic nerve activity
  • Ventrolateral medulla

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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