The case for and concerns about continuous dopamine stimulation in Parkinson's disease.

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2 Citations (Scopus)

Abstract

Delivery of levodopa or other dopaminergic agents to the striatum is a critical determinant of the clinical response and may account for many of the fluctations in response ("on-off"). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalJournal of Neural Transmission, Supplement
Volume27
StatePublished - 1988

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Dopamine Agents
Drug and Narcotic Control
Levodopa
Drug Delivery Systems
Synaptic Transmission
Parkinson Disease
Dopamine
Down-Regulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "The case for and concerns about continuous dopamine stimulation in Parkinson's disease.",
abstract = "Delivery of levodopa or other dopaminergic agents to the striatum is a critical determinant of the clinical response and may account for many of the fluctations in response ({"}on-off{"}). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotransmission.",
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