The case for and concerns about continuous dopamine stimulation in Parkinson's disease.

J. G. Nutt

doi:10.1007/978-3-7091-8954-2_2

The case for and concerns about continuous dopamine stimulation in Parkinson's disease.

J. G. Nutt

Neurology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Delivery of levodopa or other dopaminergic agents to the striatum is a critical determinant of the clinical response and may account for many of the fluctations in response ("on-off"). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotransmission.

Original language	English (US)
Pages (from-to)	11-15
Number of pages	5
Journal	Journal of neural transmission. Supplementum
Volume	27
DOIs	https://doi.org/10.1007/978-3-7091-8954-2_2
State	Published - 1988

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/978-3-7091-8954-2_2

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N2 - Delivery of levodopa or other dopaminergic agents to the striatum is a critical determinant of the clinical response and may account for many of the fluctations in response ("on-off"). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotransmission.

AB - Delivery of levodopa or other dopaminergic agents to the striatum is a critical determinant of the clinical response and may account for many of the fluctations in response ("on-off"). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotransmission.

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The case for and concerns about continuous dopamine stimulation in Parkinson's disease.

Abstract

ASJC Scopus subject areas

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