The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the phospholamban-SERCA axis a therapeutic target?

Stephen Heitner, Steven M. Hollenberg

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.

Original languageEnglish (US)
Pages (from-to)132
Number of pages1
JournalCritical Care
Volume13
Issue number2
StatePublished - 2009
Externally publishedYes

Fingerprint

Lipopolysaccharides
Sepsis
Critical Care
Therapeutics
phospholamban

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{cad98b80dc2046ca8a08bf017e51573e,
title = "The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the phospholamban-SERCA axis a therapeutic target?",
abstract = "Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.",
author = "Stephen Heitner and Hollenberg, {Steven M.}",
year = "2009",
language = "English (US)",
volume = "13",
pages = "132",
journal = "Critical Care",
issn = "1364-8535",
publisher = "BioMed Central Ltd.",
number = "2",

}

TY - JOUR

T1 - The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats

T2 - is the phospholamban-SERCA axis a therapeutic target?

AU - Heitner, Stephen

AU - Hollenberg, Steven M.

PY - 2009

Y1 - 2009

N2 - Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.

AB - Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.

UR - http://www.scopus.com/inward/record.url?scp=69849086446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69849086446&partnerID=8YFLogxK

M3 - Article

C2 - 19439042

AN - SCOPUS:69849086446

VL - 13

SP - 132

JO - Critical Care

JF - Critical Care

SN - 1364-8535

IS - 2

ER -