TY - JOUR
T1 - The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats
T2 - is the phospholamban-SERCA axis a therapeutic target?
AU - Heitner, Stephen B.
AU - Hollenberg, Steven M.
PY - 2009
Y1 - 2009
N2 - Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.
AB - Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.
UR - http://www.scopus.com/inward/record.url?scp=69849086446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69849086446&partnerID=8YFLogxK
U2 - 10.1186/cc7752
DO - 10.1186/cc7752
M3 - Comment/debate
C2 - 19439042
AN - SCOPUS:69849086446
SN - 1364-8535
VL - 13
SP - 132
JO - Critical care (London, England)
JF - Critical care (London, England)
IS - 2
ER -