The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the phospholamban-SERCA axis a therapeutic target?

Stephen B. Heitner, Steven M. Hollenberg

    Research output: Contribution to journalComment/debate

    7 Scopus citations

    Abstract

    Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.

    Original languageEnglish (US)
    Number of pages1
    JournalCritical care (London, England)
    Volume13
    Issue number2
    StatePublished - 2009

    ASJC Scopus subject areas

    • Critical Care and Intensive Care Medicine

    Fingerprint Dive into the research topics of 'The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the phospholamban-SERCA axis a therapeutic target?'. Together they form a unique fingerprint.

  • Cite this