@article{5c4ce08a8df6418a8f5f40974d823238,
title = "The calcium paradox of essential hypertension",
abstract = "Three disparate observations-that calcium mediates vascular smooth muscle contraction, that calcium channel blockers lower blood pressure, and that increased dietary calcium intake can also ameliorate hypertension-constitute somewhat of a paradox. The complex interrelationships between calcium metabolism and essential hypertension are discussed in this review. Recent evidence suggests possible defects in intracellular calcium transport or in calcium binding in essential hypertension. This evidence, and the paradoxical therapeutic efficacy of both calcium channel blockers and supplemental dietary calcium, can be integrated into a single theoretic construct.",
author = "Mccarron, {David A.} and Morris, {Cynthia D.} and Richard Bukoski",
note = "Funding Information: From the Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland, Oregon. The authors{\textquoteright} original research cited in this article was supported by grants from the M. J. Mur-dock Charitable Trust, the American Heart Association, the National Dairy Council, the General Clinical Research Center of the United States Public Health Services, and the National Dairy Board for Promotion and Research administered by the National Dairy Council. Requests for reprints should be addressed to Dr. David A. McCarron, Division of NephrologyIHypertension, Oregon Health Sciences University, 3181 Sam Jackson Park Road Southwest, Portland, Oregon 97201. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "1987",
month = jan,
day = "26",
doi = "10.1016/0002-9343(87)90268-3",
language = "English (US)",
volume = "82",
pages = "27--33",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "1 SUPPL. 2",
}