The broad spectrum of inherited growth hormone insensitivity syndrome

Linda B. Johnston, Katie A. Woods, Stephen J. Rose, Adrian J.L. Clark, Martin O. Savage

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Growth hormone (GH) insensitivity syndrome (GHIS) results in severe short stature and metabolic disturbances, but when this disorder is studied in more detail it is clear that there is marked clinical and biochemical heterogeneity. Many genetic defects of the GH receptor have been reported in inherited GHIS, but it now seems likely that some cases might be the result of defects of other genes or of links in the post-receptor cascade.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalTrends in Endocrinology and Metabolism
Volume9
Issue number6
DOIs
StatePublished - Aug 1 1998

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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