TY - JOUR
T1 - Chapter 16 The brain nicotinic acetylcholine receptor gene family
AU - Heinemann, S.
AU - Boulter, J.
AU - Deneris, E.
AU - Conolly, J.
AU - Duvoisin, R.
AU - Papke, R.
AU - Patrick, J.
N1 - Funding Information:
The work reviewed in this paper was supported by the National Institutes of Health, U.S.A., National Institute of Neurological and Communicative Disorders and Stroke (S.H. and J.P.), and the Muscular Dystrophy Association of America (S.H. and J.P.).
PY - 1990/1/1
Y1 - 1990/1/1
N2 - During the past decade, the availability of radiolabeled nicotine with high specific activity has led to the discovery and mapping of nicotine binding sites in the mammalian brain. These data suggested that the mammalian brain contains an important nicotinic receptor system. This chapter discusses the family of brain nicotinic acetylcholine receptors that have discovered in the past few years through the use of the molecular genetic approach. It identifies seven genes in the rat or mouse genome that code for proteins with homology to the nicotinic acetylcholine receptor. These genes are expressed in the mammalian brain and in some peripheral neurons. The primary structures of the brain nicotinic receptor subunits expressed in the brain have been deduced from the sequences of the cDNA clones. Analysis of the hydrophobicity profiles of the brain nicotinic receptor subunits suggests that they fold through the membrane in an identical manner to the Torpedo fish nicotinic receptor.
AB - During the past decade, the availability of radiolabeled nicotine with high specific activity has led to the discovery and mapping of nicotine binding sites in the mammalian brain. These data suggested that the mammalian brain contains an important nicotinic receptor system. This chapter discusses the family of brain nicotinic acetylcholine receptors that have discovered in the past few years through the use of the molecular genetic approach. It identifies seven genes in the rat or mouse genome that code for proteins with homology to the nicotinic acetylcholine receptor. These genes are expressed in the mammalian brain and in some peripheral neurons. The primary structures of the brain nicotinic receptor subunits expressed in the brain have been deduced from the sequences of the cDNA clones. Analysis of the hydrophobicity profiles of the brain nicotinic receptor subunits suggests that they fold through the membrane in an identical manner to the Torpedo fish nicotinic receptor.
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U2 - 10.1016/S0079-6123(08)63177-5
DO - 10.1016/S0079-6123(08)63177-5
M3 - Article
C2 - 2087557
AN - SCOPUS:0025607855
SN - 0079-6123
VL - 86
SP - 195
EP - 203
JO - Progress in Brain Research
JF - Progress in Brain Research
IS - C
ER -