The biology of ovarian cancer

New opportunities for translation

Robert C. Bast, Bryan Hennessy, Gordon Mills

Research output: Contribution to journalReview article

823 Citations (Scopus)

Abstract

Over the past two decades, the 5-year survival for ovarian cancer patients has substantially improved owing to more effective surgery and treatment with empirically optimized combinations of cytotoxic drugs, but the overall cure rate remains approximately 30%. Many investigators think that further empirical trials using combinations of conventional agents are likely to produce only modest incremental improvements in outcome. Given the heterogeneity of this disease, increases in long-term survival might be achieved by translating recent insights at the molecular and cellular levels to personalize individual strategies for treatment and to optimize early detection.

Original languageEnglish (US)
Pages (from-to)415-428
Number of pages14
JournalNature Reviews Cancer
Volume9
Issue number6
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

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Ovarian Neoplasms
Survival
Drug Combinations
Research Personnel
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The biology of ovarian cancer : New opportunities for translation. / Bast, Robert C.; Hennessy, Bryan; Mills, Gordon.

In: Nature Reviews Cancer, Vol. 9, No. 6, 01.01.2009, p. 415-428.

Research output: Contribution to journalReview article

Bast, Robert C. ; Hennessy, Bryan ; Mills, Gordon. / The biology of ovarian cancer : New opportunities for translation. In: Nature Reviews Cancer. 2009 ; Vol. 9, No. 6. pp. 415-428.
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