The attenuation of dysfunctional emotional processing with stimulant medication: An fMRI study of adolescents with ADHD

Jonathan Posner, Tiago V. Maia, Damien Fair, Bradley S. Peterson, Edmund J. Sonuga-Barke, Bonnie Nagel

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Functional neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the neural correlates of cognitive control. However, for many youths with ADHD, emotional lability is an important clinical feature of the disorder. We aimed to identify the neural substrates associated with emotional lability that were distinct from impairments in cognitive control and to assess the effects that stimulants have on those substrates. We used functional magnetic resonance imaging (fMRI) to assess neural activity in adolescents with (N=15) and without (N=15) ADHD while they performed cognitive and emotional versions of the Stroop task that engage cognitive control and emotional processing, respectively. The participants with ADHD were scanned both on and off stimulant medication in a counterbalanced fashion. Controlling for differences in cognitive control, we found that during the emotional Stroop task, adolescents with ADHD as compared with controls demonstrated atypical activity in the medial prefrontal cortex (mPFC). Stimulants attenuated activity in the mPFC to levels comparable with controls.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalPsychiatry Research - Neuroimaging
Volume193
Issue number3
DOIs
StatePublished - Sep 30 2011

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Attention Deficit Disorder with Hyperactivity
Magnetic Resonance Imaging
Prefrontal Cortex
Functional Neuroimaging

Keywords

  • Cognitive control
  • Emotional lability
  • Medial prefrontal cortex
  • Stroop

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

The attenuation of dysfunctional emotional processing with stimulant medication : An fMRI study of adolescents with ADHD. / Posner, Jonathan; Maia, Tiago V.; Fair, Damien; Peterson, Bradley S.; Sonuga-Barke, Edmund J.; Nagel, Bonnie.

In: Psychiatry Research - Neuroimaging, Vol. 193, No. 3, 30.09.2011, p. 151-160.

Research output: Contribution to journalArticle

Posner, Jonathan ; Maia, Tiago V. ; Fair, Damien ; Peterson, Bradley S. ; Sonuga-Barke, Edmund J. ; Nagel, Bonnie. / The attenuation of dysfunctional emotional processing with stimulant medication : An fMRI study of adolescents with ADHD. In: Psychiatry Research - Neuroimaging. 2011 ; Vol. 193, No. 3. pp. 151-160.
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