The association of HLA and immune responses to bovine collagen implants

E. E. Vanderveen, J. P. McCoy, W. Schade, J. J. Kapur, T. Hamilton, C. Ragsdale, R. C. Grekin, Neil Swanson

Research output: Contribution to journalArticle

Abstract

The HLA type of patients with various kinds of immune reactions to bovine collagen implants were evaluated to determine a possible genetic basis for such responses. All patients suffering adverse clinical reactions to bovine collagen implants were lacking the HLA-DR4 antigen. All patients who received multiple bovine collagen injections without having adverse clinical reactions were lacking HLA-B5 and HLA-DR5 and had a significantly increased incidence of HLA-DR4. Combinations of histocompatibility antigens may influence immune response to bovine collagen implants.

Original languageEnglish (US)
Pages (from-to)650-654
Number of pages5
JournalArchives of Dermatology
Volume122
Issue number6
DOIs
StatePublished - 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Dermatology

Cite this

Vanderveen, E. E., McCoy, J. P., Schade, W., Kapur, J. J., Hamilton, T., Ragsdale, C., Grekin, R. C., & Swanson, N. (1986). The association of HLA and immune responses to bovine collagen implants. Archives of Dermatology, 122(6), 650-654. https://doi.org/10.1001/archderm.122.6.650