The association of HLA and immune responses to bovine collagen implants

E. E. Vanderveen; J. P. McCoy; W. Schade; J. J. Kapur; T. Hamilton; C. Ragsdale; R. C. Grekin; Neil Swanson

doi:10.1001/archderm.122.6.650

The association of HLA and immune responses to bovine collagen implants

E. E. Vanderveen, J. P. McCoy, W. Schade, J. J. Kapur, T. Hamilton, C. Ragsdale, R. C. Grekin, Neil Swanson

Research output: Contribution to journal › Article › peer-review

Abstract

The HLA type of patients with various kinds of immune reactions to bovine collagen implants were evaluated to determine a possible genetic basis for such responses. All patients suffering adverse clinical reactions to bovine collagen implants were lacking the HLA-DR4 antigen. All patients who received multiple bovine collagen injections without having adverse clinical reactions were lacking HLA-B5 and HLA-DR5 and had a significantly increased incidence of HLA-DR4. Combinations of histocompatibility antigens may influence immune response to bovine collagen implants.

Original language	English (US)
Pages (from-to)	650-654
Number of pages	5
Journal	Archives of Dermatology
Volume	122
Issue number	6
DOIs	https://doi.org/10.1001/archderm.122.6.650
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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10.1001/archderm.122.6.650

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AU - Schade, W.

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AU - Ragsdale, C.

AU - Grekin, R. C.

AU - Swanson, Neil

PY - 1986

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AB - The HLA type of patients with various kinds of immune reactions to bovine collagen implants were evaluated to determine a possible genetic basis for such responses. All patients suffering adverse clinical reactions to bovine collagen implants were lacking the HLA-DR4 antigen. All patients who received multiple bovine collagen injections without having adverse clinical reactions were lacking HLA-B5 and HLA-DR5 and had a significantly increased incidence of HLA-DR4. Combinations of histocompatibility antigens may influence immune response to bovine collagen implants.

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The association of HLA and immune responses to bovine collagen implants

Abstract

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