The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth: A case-control study

R. Miller, R. Smiley, E. A. Thom, W. A. Grobman, J. D. Iams, B. M. Mercer, G. Saade, A. T. Tita, U. M. Reddy, D. J. Rouse, Y. Sorokin, S. C. Blackwell, M. S. Esplin, Jorge Tolosa, S. N. Caritis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective To determine whether β2-adrenoceptor (β2AR) genotype is associated with shortening of the cervix or with preterm birth (PTB) risk among women with a short cervix in the second trimester. Design A case-control ancillary study to a multicentre randomised controlled trial. Setting Fourteen participating centres of the Maternal-Fetal Medicine Units Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Population Four hundred thirty-nine women, including 315 with short cervix and 124 with normal cervical length. Methods Nulliparous women with cervical length 2AR genotype was determined at positions encoding for amino acid residues 16 and 27. Main outcome measures Genotype distributions were compared between case and control groups. Within the short cervix group, pregnancy outcomes were compared by genotype, with a primary outcome of PTB 2AR genotype does not seem to be associated with short cervical length or with PTB following the second-trimester identification of a short cervix. Influences on PTB associated with β2AR genotype do not appear to involve a short cervix pathway.

Original languageEnglish (US)
Pages (from-to)1387-1394
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume122
Issue number10
DOIs
StatePublished - Sep 1 2015

Fingerprint

Premature Birth
Cervix Uteri
Adrenergic Receptors
Case-Control Studies
Genotype
Second Pregnancy Trimester
National Institute of Child Health and Human Development (U.S.)
Pregnancy Outcome
Randomized Controlled Trials
Mothers
Medicine
Outcome Assessment (Health Care)
Amino Acids
Control Groups
Population

Keywords

  • Beta-2 adrenoceptor
  • genotype
  • short cervix

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth : A case-control study. / Miller, R.; Smiley, R.; Thom, E. A.; Grobman, W. A.; Iams, J. D.; Mercer, B. M.; Saade, G.; Tita, A. T.; Reddy, U. M.; Rouse, D. J.; Sorokin, Y.; Blackwell, S. C.; Esplin, M. S.; Tolosa, Jorge; Caritis, S. N.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 122, No. 10, 01.09.2015, p. 1387-1394.

Research output: Contribution to journalArticle

Miller, R, Smiley, R, Thom, EA, Grobman, WA, Iams, JD, Mercer, BM, Saade, G, Tita, AT, Reddy, UM, Rouse, DJ, Sorokin, Y, Blackwell, SC, Esplin, MS, Tolosa, J & Caritis, SN 2015, 'The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth: A case-control study', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 122, no. 10, pp. 1387-1394. https://doi.org/10.1111/1471-0528.13243
Miller, R. ; Smiley, R. ; Thom, E. A. ; Grobman, W. A. ; Iams, J. D. ; Mercer, B. M. ; Saade, G. ; Tita, A. T. ; Reddy, U. M. ; Rouse, D. J. ; Sorokin, Y. ; Blackwell, S. C. ; Esplin, M. S. ; Tolosa, Jorge ; Caritis, S. N. / The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth : A case-control study. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2015 ; Vol. 122, No. 10. pp. 1387-1394.
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