The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth: A case-control study

R. Miller, R. Smiley, E. A. Thom, W. A. Grobman, J. D. Iams, B. M. Mercer, G. Saade, A. T. Tita, U. M. Reddy, D. J. Rouse, Y. Sorokin, S. C. Blackwell, M. S. Esplin, Jorge Tolosa, S. N. Caritis

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Objective To determine whether β2-adrenoceptor (β2AR) genotype is associated with shortening of the cervix or with preterm birth (PTB) risk among women with a short cervix in the second trimester. Design A case-control ancillary study to a multicentre randomised controlled trial. Setting Fourteen participating centres of the Maternal-Fetal Medicine Units Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Population Four hundred thirty-nine women, including 315 with short cervix and 124 with normal cervical length. Methods Nulliparous women with cervical length 2AR genotype was determined at positions encoding for amino acid residues 16 and 27. Main outcome measures Genotype distributions were compared between case and control groups. Within the short cervix group, pregnancy outcomes were compared by genotype, with a primary outcome of PTB 2AR genotype does not seem to be associated with short cervical length or with PTB following the second-trimester identification of a short cervix. Influences on PTB associated with β2AR genotype do not appear to involve a short cervix pathway.

Original languageEnglish (US)
Pages (from-to)1387-1394
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number10
Publication statusPublished - Sep 1 2015



  • Beta-2 adrenoceptor
  • genotype
  • short cervix

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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