The Association between BMI and QCT-Derived Proximal Hip Structure and Strength in Older Men

A Cross-Sectional Study

Jian Shen, Carrie Nielson, Lynn Marshall, David C. Lee, Tony M. Keaveny, Eric Orwoll

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Although higher body mass index (BMI) is associated with higher bone mineral density, recent evidence indicates that increased BMI may not be consistently associated with reduced hip fracture risk. Moreover, substantial proportions of hip fractures occur among overweight and obese men and women. The role of increased BMI and obesity on bone density, structure, and strength at the hip is not well understood. We conducted cross-sectional analyses between BMI and various density and structure measures derived from quantitative computed tomography (QCT)-scans of the proximal femur, in 3067 men (mean age: 73 y) from the Osteoporotic Fractures in Men Study (MrOS). Finite element (FE) analysis of hip QCT scans was performed for a subcohort of 672 men to provide a measure of femoral strength for a simulated sideways fall. The impact force was estimated using patient-specific weight and height information. Multivariable general linear models were used to examine the associations between BMI and hip QCT measures. The relationship of BMI with hip QCT measures was significantly different between men categorized as non-obese and obese (P for interaction ≤ 0.014). For non-obese men (BMI <30), increasing BMI was associated with higher integral, cortical and trabecular vBMD, integral volume, cross-sectional area, and percent cortical volume (all p

Original languageEnglish (US)
Pages (from-to)1301-1308
Number of pages8
JournalJournal of Bone and Mineral Research
Volume30
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Hip
Body Mass Index
Cross-Sectional Studies
Tomography
Hip Fractures
Bone Density
Finite Element Analysis
Osteoporotic Fractures
Thigh
Femur
Linear Models
Obesity
Weights and Measures

Keywords

  • HIP FRACTURE RISK
  • HIP STRENGTH
  • HIP STRUCTURE
  • MEN
  • OBESITY

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

The Association between BMI and QCT-Derived Proximal Hip Structure and Strength in Older Men : A Cross-Sectional Study. / Shen, Jian; Nielson, Carrie; Marshall, Lynn; Lee, David C.; Keaveny, Tony M.; Orwoll, Eric.

In: Journal of Bone and Mineral Research, Vol. 30, No. 7, 01.07.2015, p. 1301-1308.

Research output: Contribution to journalArticle

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