The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus

Tania F. Esakoff, Yvonne W. Cheng, Teresa N. Sparks, Aaron B. Caughey

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Objective: The objective of the study was to examine the association between birthweight of 4000 g or greater and perinatal outcomes in women with and without gestational diabetes mellitus (GDM). Study Design: This was a retrospective cohort study of 36,241 singleton pregnancies stratified by the diagnosis of GDM, with presence or absence of birthweight of 4000 g or greater. Outcomes examined included neonatal hyperbilirubinemia, hypoglycemia, respiratory distress syndrome (RDS), shoulder dystocia, and Erb's palsy. χ2 tests and multivariable logistic regression analyses were used to control for confounders. Results: In women with GDM, neonates with a birthweight of 4000 g or greater, compared with those with a birthweight of less than 4000 g, had higher frequencies of hypoglycemia (5.3% vs 2.6%; P = .04), RDS (4.0% vs 1.5%; P = .03), shoulder dystocia (10.5% vs 1.6%; P < .001), and Erb's palsy (2.6% vs 0.2%; P < .001). Even without GDM, these outcomes occurred more frequently in infants with birthweight of 4000 g or greater. GDM increases the odds of adverse outcomes associated with birthweight of 4000 g or greater, particularly shoulder dystocia (adjusted odds ratios [aORs], 16.4 [GDM] vs 9.6 [non-GDM] and Erb's palsy (aORs, 41.9 [GDM] vs 6.7 [non-GDM]). Conclusion: Birthweight of 4000 g or greater is associated with a higher incidence of adverse perinatal outcomes such that neonatal providers should be alerted.

Original languageEnglish (US)
Pages (from-to)672.e1-672.e4
JournalAmerican journal of obstetrics and gynecology
Volume200
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • birthweight of 4000 g or greater
  • gestational diabetes
  • perinatal outcomes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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