The association between abnormal birth history and growth in children with CKD

Larry A. Greenbaum, Alvaro Muñoz, Michael F. Schneider, Frederick J. Kaskel, David J. Askenazi, Randall Jenkins, Hilary Hotchkiss, Marva Moxey-Mims, Susan L. Furth, Bradley A. Warady

Research output: Contribution to journalArticle

50 Scopus citations


Background and objectives: Poor linear growth is a well described complication of chronic kidney disease (CKD). This study evaluated whether abnormal birth history defined by low birth weight (LBW; 2, 21% had a glomerular diagnosis, and 52% had CKD for ≥90% of their lifetime. Results: A high prevalence of LBW (17%), SGA (14%), prematurity (12%), and ICU after delivery (40%) was observed. Multivariate analyses demonstrated a negative effect of LBW (-0.43 ± 0.14; P <0.01 for height and -0.37 ± 0.16; P = 0.02 for weight) and of SGA (-0.29 ± 0.16; P = 0.07 for height and -0.41 ± 0.19; P = 0.03 for weight) on current height and weight. In children with glomerular versus nonglomerular diagnoses, the effect of SGA (-1.08 versus -0.18; P = 0.029) on attained weight was more pronounced in children with a glomerular diagnosis. Conclusions: LBW and SGA are novel risk factors for short stature and lower weight percentiles in children with mild to moderate CKD independent of kidney function.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Issue number1
Publication statusPublished - Jan 1 2011
Externally publishedYes


ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Greenbaum, L. A., Muñoz, A., Schneider, M. F., Kaskel, F. J., Askenazi, D. J., Jenkins, R., ... Warady, B. A. (2011). The association between abnormal birth history and growth in children with CKD. Clinical Journal of the American Society of Nephrology, 6(1), 14-21.