The arthritis of mixed connective tissue disease

Robert (Rob) Bennett, D. J. O'Connell

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    Twenty patients with mixed connective tissue disease were followed for 5 years. Arthritis occurred in all 20 patients, being the presenting complaint in 11 patients. The joints most frequently involved were the proximal interphalangeal (PIP), metacarpophalangeal (MCP), wrists, metatarsophalangeal (MTP), and knee; the distribution tended to be symmetrical, mimicking early rheumatoid arthritis. Joint deformities occurred in 6 patients, but apart from 1 patient with arthritis mutilans, significant functional impairment was not encountered. Radiologically small punched out bone erosions, asymmetrically distributed, were the most characteristic finding; other notable changes were aseptic necrosis, tuft erosions, and periarticular calcification. Joint effusions were non-inflammatory, the cellular content was predominantly lymphocytic and the C3 level was normal. Most cases were controlled with non-steroidal anti-inflammatory agents and invariably responded to prednisone ≤7.5 mg/day.

    Original languageEnglish (US)
    Pages (from-to)397-403
    Number of pages7
    JournalAnnals of the Rheumatic Diseases
    Volume37
    Issue number5
    StatePublished - 1978

    Fingerprint

    Mixed Connective Tissue Disease
    Arthritis
    Erosion
    Tissue
    Non-Steroidal Anti-Inflammatory Agents
    Prednisone
    Joints
    Bone
    Wrist
    Rheumatoid Arthritis
    Knee
    Necrosis
    Bone and Bones

    ASJC Scopus subject areas

    • Immunology
    • Rheumatology

    Cite this

    Bennett, R. R., & O'Connell, D. J. (1978). The arthritis of mixed connective tissue disease. Annals of the Rheumatic Diseases, 37(5), 397-403.

    The arthritis of mixed connective tissue disease. / Bennett, Robert (Rob); O'Connell, D. J.

    In: Annals of the Rheumatic Diseases, Vol. 37, No. 5, 1978, p. 397-403.

    Research output: Contribution to journalArticle

    Bennett, RR & O'Connell, DJ 1978, 'The arthritis of mixed connective tissue disease', Annals of the Rheumatic Diseases, vol. 37, no. 5, pp. 397-403.
    Bennett, Robert (Rob) ; O'Connell, D. J. / The arthritis of mixed connective tissue disease. In: Annals of the Rheumatic Diseases. 1978 ; Vol. 37, No. 5. pp. 397-403.
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