Abstract
The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor IκB subclass α. NF-κB/IκB signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.
Original language | English (US) |
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Pages (from-to) | 425-439 |
Number of pages | 15 |
Journal | Plant Cell |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Plant Science
- Cell Biology