The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB

John Ryals, Kristianna Weymann, Kay Lawton, Leslie Friedrich, Daniel Ellis, Henry York Steiner, Jay Johnson, Terrence P. Delaney, Taco Jesse, Pieter Vos, Scott Uknes

Research output: Contribution to journalArticle

353 Citations (Scopus)

Abstract

The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor IκB subclass α. NF-κB/IκB signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.

Original languageEnglish (US)
Pages (from-to)425-439
Number of pages15
JournalPlant Cell
Volume9
Issue number3
DOIs
StatePublished - Mar 1997
Externally publishedYes

Fingerprint

Arabidopsis Proteins
Transcription Factors
transcription factors
Arabidopsis
systemic acquired resistance
Disease Resistance
Genes
disease resistance
signal transduction
Signal Transduction
genes
proteins
Amino Acid Sequence Homology
pathogenesis-related proteins
organisms
sequence homology
defense mechanisms
Drosophila
Organism Cloning
Mammals

ASJC Scopus subject areas

  • Plant Science
  • Cell Biology

Cite this

Ryals, J., Weymann, K., Lawton, K., Friedrich, L., Ellis, D., Steiner, H. Y., ... Uknes, S. (1997). The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB. Plant Cell, 9(3), 425-439. https://doi.org/10.1105/tpc.9.3.425

The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB. / Ryals, John; Weymann, Kristianna; Lawton, Kay; Friedrich, Leslie; Ellis, Daniel; Steiner, Henry York; Johnson, Jay; Delaney, Terrence P.; Jesse, Taco; Vos, Pieter; Uknes, Scott.

In: Plant Cell, Vol. 9, No. 3, 03.1997, p. 425-439.

Research output: Contribution to journalArticle

Ryals, J, Weymann, K, Lawton, K, Friedrich, L, Ellis, D, Steiner, HY, Johnson, J, Delaney, TP, Jesse, T, Vos, P & Uknes, S 1997, 'The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB', Plant Cell, vol. 9, no. 3, pp. 425-439. https://doi.org/10.1105/tpc.9.3.425
Ryals, John ; Weymann, Kristianna ; Lawton, Kay ; Friedrich, Leslie ; Ellis, Daniel ; Steiner, Henry York ; Johnson, Jay ; Delaney, Terrence P. ; Jesse, Taco ; Vos, Pieter ; Uknes, Scott. / The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB. In: Plant Cell. 1997 ; Vol. 9, No. 3. pp. 425-439.
@article{b66489be622e4b9096d616897edf920a,
title = "The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB",
abstract = "The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor IκB subclass α. NF-κB/IκB signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.",
author = "John Ryals and Kristianna Weymann and Kay Lawton and Leslie Friedrich and Daniel Ellis and Steiner, {Henry York} and Jay Johnson and Delaney, {Terrence P.} and Taco Jesse and Pieter Vos and Scott Uknes",
year = "1997",
month = "3",
doi = "10.1105/tpc.9.3.425",
language = "English (US)",
volume = "9",
pages = "425--439",
journal = "Plant Cell",
issn = "1040-4651",
publisher = "American Society of Plant Biologists",
number = "3",

}

TY - JOUR

T1 - The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB

AU - Ryals, John

AU - Weymann, Kristianna

AU - Lawton, Kay

AU - Friedrich, Leslie

AU - Ellis, Daniel

AU - Steiner, Henry York

AU - Johnson, Jay

AU - Delaney, Terrence P.

AU - Jesse, Taco

AU - Vos, Pieter

AU - Uknes, Scott

PY - 1997/3

Y1 - 1997/3

N2 - The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor IκB subclass α. NF-κB/IκB signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.

AB - The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor IκB subclass α. NF-κB/IκB signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.

UR - http://www.scopus.com/inward/record.url?scp=0031106159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031106159&partnerID=8YFLogxK

U2 - 10.1105/tpc.9.3.425

DO - 10.1105/tpc.9.3.425

M3 - Article

C2 - 9090885

AN - SCOPUS:0031106159

VL - 9

SP - 425

EP - 439

JO - Plant Cell

JF - Plant Cell

SN - 1040-4651

IS - 3

ER -