The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB

John Ryals, Kris Weymann, Kay Lawton, Leslie Friedrich, Daniel Ellis, Henry York Steiner, Jay Johnson, Terrence P. Delaney, Taco Jesse, Pieter Vos, Scott Uknes

Research output: Contribution to journalArticle

358 Scopus citations

Abstract

The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor IκB subclass α. NF-κB/IκB signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.

Original languageEnglish (US)
Pages (from-to)425-439
Number of pages15
JournalPlant Cell
Volume9
Issue number3
DOIs
StatePublished - Mar 1 1997

ASJC Scopus subject areas

  • Plant Science
  • Cell Biology

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    Ryals, J., Weymann, K., Lawton, K., Friedrich, L., Ellis, D., Steiner, H. Y., Johnson, J., Delaney, T. P., Jesse, T., Vos, P., & Uknes, S. (1997). The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB. Plant Cell, 9(3), 425-439. https://doi.org/10.1105/tpc.9.3.425