Abstract
The phosphatidylinositol 3′ kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and survival, is mutated or activated in a wide variety of cancers. Akt appears to be a key central node in this pathway and thus is an attractive target for targeted molecular therapy. We demonstrated that Akt is highly phosphorylated in thyroid cancer cell lines and human thyroid cancer specimens, and hypothesised that KP372-1, an Akt inhibitor, would block signalling through the PI3K pathway and inhibit cell proliferation while inducing apoptosis of thyroid cancer cells, KP372-1 blocked signalling downstream of Akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis. As thyroid cancer consistently expresses phosphorylated Akt and KP372-1 effectively blocks Akt signalling, further preclinical evaluation of this compound for treatment of thyroid cancer is warranted.
Original language | English (US) |
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Pages (from-to) | 1899-1905 |
Number of pages | 7 |
Journal | British Journal of Cancer |
Volume | 92 |
Issue number | 10 |
DOIs | |
State | Published - May 23 2005 |
Externally published | Yes |
Keywords
- Anaplastic thyroid cancer
- Growth factors
- KP372-1
- Molecular therapy
ASJC Scopus subject areas
- Oncology
- Cancer Research