The adverse effects of octreotide on wound healing in rats

Brad E. Waddell, William C. Calton, Sidney R. Steinberg, Robert Martindale

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Octreotide acetate is a long-acting somatostatin analogue with protean physiologic effects. It is used primarily as an inhibitory paracrine hormone to treat a variety of medical and surgical disorders, including endocrine tumors and several gastrointestinal hypersecretory states. Because of octreotide's known inhibition of multiple trophic and anabolic hormones, we suspected that it may have deleterious effects on wound healing. Twenty-four rats were randomized to one of three groups: control, steroid (a negative control), or octreotide. Dorsal midline incisions were made and closed primarily. Wound-breaking strength measurements were performed 7 days later. The mean peak load (± standard error of the mean) for each group was calculated: control = 754 ± 89 g; steroid = 378 ± 32 g; and octreotide = 427 ± 41 g. The difference between the control group and each of the other groups was statistically significant with P <0.030. We conclude that octreotide has significant adverse effects on wound healing in the rat model and that these effects are comparable in magnitude to those caused by steroids.

Original languageEnglish (US)
Pages (from-to)446-449
Number of pages4
JournalAmerican Surgeon
Volume63
Issue number5
StatePublished - May 1997
Externally publishedYes

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Octreotide
Wound Healing
Steroids
Hormones
Control Groups
Somatostatin
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Waddell, B. E., Calton, W. C., Steinberg, S. R., & Martindale, R. (1997). The adverse effects of octreotide on wound healing in rats. American Surgeon, 63(5), 446-449.

The adverse effects of octreotide on wound healing in rats. / Waddell, Brad E.; Calton, William C.; Steinberg, Sidney R.; Martindale, Robert.

In: American Surgeon, Vol. 63, No. 5, 05.1997, p. 446-449.

Research output: Contribution to journalArticle

Waddell, BE, Calton, WC, Steinberg, SR & Martindale, R 1997, 'The adverse effects of octreotide on wound healing in rats', American Surgeon, vol. 63, no. 5, pp. 446-449.
Waddell BE, Calton WC, Steinberg SR, Martindale R. The adverse effects of octreotide on wound healing in rats. American Surgeon. 1997 May;63(5):446-449.
Waddell, Brad E. ; Calton, William C. ; Steinberg, Sidney R. ; Martindale, Robert. / The adverse effects of octreotide on wound healing in rats. In: American Surgeon. 1997 ; Vol. 63, No. 5. pp. 446-449.
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