The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

Sarah C. Petersen, Rong Luo, Ines Liebscher, Stefanie Giera, Sung Jin Jeong, Amit Mogha, Monica Ghidinelli, M. Laura Feltri, Torsten Schöneberg, Xianhua Piao, Kelly Monk

Research output: Contribution to journalArticle

95 Scopus citations


Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells(SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor GPR126, which undergoes autoproteolytic cleavage into an N-terminal fragment (NTF) and a seven-transmembrane-containing C-terminal fragment (CTF). Here we show that GPR126 has domain-specific functions in SC development whereby the NTF is necessary and sufficient for axon sorting, whereas the CTF promotes wrapping through cAMP elevation. These biphasic roles of GPR126 are governed by interactions with Laminin-211, which we define as a novel ligand for GPR126 that modulates receptor signaling via a tethered agonist. Our work suggests a model in which Laminin-211 mediates GPR126-induced cAMP levels to control early and late stages of SC development.

Original languageEnglish (US)
Pages (from-to)755-769
Number of pages15
Issue number4
Publication statusPublished - Jan 1 2015
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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