The acute effects of capsaicin on rat primary afferents and spinal neurons

John Williams, W. Zieglagänsberger

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Capsaicin applied to the soma of fast and slow conducting primary afferent fibers had a depolarizing action associated with an increase in membrane conductance. The depolarizing effect desensitized rapidly and was only partially reversible in slow conducting fibers. Capsaicin application to the entry zone of the appropriate dorsal rootlets led to strong excitation of dorsal horn neurons receiving multimodal input. After acute capsaicin treatment the response to noxious heat was attenuated or totally absent, while other noxious stimuli were still effective. The present data suggest that capsaicin exerts its specific degenerative action by a long-lasting depolarizing action on small-calibre fibers.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalBrain Research
Volume253
Issue number1-2
DOIs
StatePublished - Dec 16 1982
Externally publishedYes

Fingerprint

Afferent Neurons
Capsaicin
Posterior Horn Cells
Carisoprodol
Hot Temperature
Membranes

Keywords

  • capsaicin
  • primary afferents
  • spinal neurons

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

The acute effects of capsaicin on rat primary afferents and spinal neurons. / Williams, John; Zieglagänsberger, W.

In: Brain Research, Vol. 253, No. 1-2, 16.12.1982, p. 125-131.

Research output: Contribution to journalArticle

Williams, John ; Zieglagänsberger, W. / The acute effects of capsaicin on rat primary afferents and spinal neurons. In: Brain Research. 1982 ; Vol. 253, No. 1-2. pp. 125-131.
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