The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis

Jason Link, Peter J. Hurlin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The MYC family of proteins plays essential roles in embryonic development and in oncogenesis. Efforts over the past 30 years to define the transcriptional activities of MYC and how MYC functions to promote proliferation have produced evolving models of MYC function. One picture that has emerged of MYC and its partner protein MAX is of a transcription factor complex with a seemingly unique ability to stimulate the transcription of genes that are epigenetically poised for transcription and to amplify the transcription of actively transcribed genes. During lymphocyte activation, MYC is upregulated and stimulates a pro-proliferative program in part through the upregulation of a wide variety of metabolic effector genes that facilitate cell growth and cell cycle progression. MYC upregulation simultaneously sensitizes cells to apoptosis and activated lymphocytes and lymphoma cells have pro-survival attributes that allow MYC-driven proliferation to prevail. For example, the MAX-interacting protein MNT is upregulated in activated lymphocytes and was found to protect lymphocytes from MYC-dependent apoptosis. Here we review the activities of MYC, MNT and other MAX interacting proteins in the setting of T and B cell activation and oncogenesis. This article is part of a Special Issue entitled: Myc proteins in cell biology and pathology.

Original languageEnglish (US)
Pages (from-to)554-562
Number of pages9
JournalBiochimica et Biophysica Acta - General Subjects
Volume1849
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Lymphocytes
Carcinogenesis
Transcription
Genes
Proteins
Up-Regulation
Chemical activation
Cells
Cytology
Apoptosis
Cell growth
Pathology
Lymphocyte Activation
Embryonic Development
Cell Biology
Lymphoma
Cell Cycle
B-Lymphocytes
Transcription Factors
T-Lymphocytes

Keywords

  • Apoptosis
  • Lymphocytes
  • Lymphoma
  • Metabolism
  • MNT
  • MYC
  • Proliferation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis. / Link, Jason; Hurlin, Peter J.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1849, No. 5, 01.05.2015, p. 554-562.

Research output: Contribution to journalArticle

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